Comparision of the Toxicological Effects of Multi-Walled Carbon Nanotubes and Nitrogen-Doped Multi-Walled Carbon Nanotubes on Rat Lung Function

Details

• Personal Author:
  Fedan, Jeffery S. ; Russ KA ; Thompson J
• Description:
  The toxicological effects of multi-walled carbon nanotubes (MWCNT) have been widely investigated. Outcomes can range from initiating pulmonary inflammation and fibrosis to cardiovascular and central nervous system effects in animal models. Previous studies in our laboratory have shown that inhalation of MWCNT (Mitsui-7) results in airway hyperreactivity to methacholine (MCh) in rats. Nitrogen-doped multi-walled carbon nanotubes (N2-MWCNT) are MWCNT that have been functionalized to incorporate nitrogen. They are utilized in applications such as lithium batteries and as matrix fillers in composite materials. N2-MWCNT are shorter and more brittle than their MWCNT counterparts, which may reduce toxicity. The purpose of this study was to determine if exposure to N2-MWCNT results in alterations in lung function that are comparable to those observed after MWCNT exposure. Sprague-Dawley rats were administered MWCNT or N2-MWCNT (25, 50, or 250 microg) in dispersion medium by intratracheal instillation. Lung resistance (RL), dynamic compliance (Cdyn), and reactivity to MCh aerosol were examined at 1 and 7 days post-exposure. Animals exhibited increased reactivity to MCh at 1 day after treatment with 25 and 250 microg MWCNT. Additionally, baseline RL was decreased at 7 days after treatment with 50 microg MWCNT without a corresponding change in reactivity to MCh. The only alteration observed in N2-MWCNT exposed animals was a decrease in baseline RL at 7 days after 250 microg N2-MWCNT exposure, with no corresponding change in reactivity to MCh. These results suggest that N2-MWCNT are less toxic than MWCNT with respect to lung function. [Description provided by NIOSH]
• Subjects:
  Aerosols Environmental Exposure Laboratories Lung Methacholine Compounds Occupational Health Respiratory System Safety Toxicology
• Keywords:
  Airway Resistance Analytical Processes Carbon Nanotubes Dose Response Exposure Assessment Exposure Levels Inhalation Laboratory Animals Laboratory Testing Lung Function Methacholines Multi-walled Carbon Nanotubes MWCNT Nanotechnology Nanotoxicology Nitrogen Compounds Pulmonary Effects Pulmonary Function Toxic Effects

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; OSHA Region 6 ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  162
• Issue:
  1
• NIOSHTIC Number:
  nn:20051263
• Citation:
  Toxicologist 2018 Mar; 162(1):420
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6) ; Methacholine (CAS RN 55-92-5) ; Nitrogen (CAS RN 7727-37-9)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Oil and Gas Extraction
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 57th Annual Meeting and ToxExpo, March 11-15, 2018, San Antonio, Texas
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9e0349ceb916699cb32f70c7e20153e508335a73988328d63a23ae7dcfe70c35b0426137bf70f58206200802b68ec339ae83ed215e84c23670ab7862290b9c50
• Download URL:
  https://stacks.cdc.gov/view/cdc/211320/cdc_211320_DS1.pdf
• File Type:
  [PDF - 832.61 KB ]