The Effect of Inhalant Organic Dust on Bone Health

Details

• Personal Author:
  Carrington JM ; Poole JA
• Description:
  Purpose of Review: Agriculture remains a major economic sector globally, and workers experience high rates of chronic inflammatory lung and musculoskeletal diseases. Whereas obstructive pulmonary diseases are known risk factors for bone loss, the underlying relationship between lung inflammation and bone health is not well known. Recent Findings: An agriculture organic dust extract inhalation animal model has recently linked lung injury-induced inflammation to systemic bone loss. This process is dependent upon lipopolysaccharide and the toll-like receptor 4 (TLR4) signaling pathway. Downstream systemic interleukin-6 is a key mediator that subsequently activates osteoclastogenesis. Age is a host factor that impacted bone disease with younger mice demonstrating increased susceptibility to bone loss following inhalant exposures as compared to older mice. Supplemental dietary vitamin D was shown to prevent organic dust-induced bone loss, but not lung disease, in animals. Summary: Recent animal studies provide new mechanistic insight into the lung-bone inflammatory axis. Host factors, diet, and lipopolysaccharide/TLR4 signaling pathways play a significant role in explaining how inhalant organic dust exposures impact bone health. These investigations might lead to specific targeted therapeutic approaches. [Description provided by NIOSH]
• Subjects:
  Agriculture Dust Farmers Immune System Lipids Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Agricultural Workers Author Keywords: Organicdust Bone Bone Disorders Chronic Inflammation COPD Endotoxin Immune Reaction Interleukin(IL)-6 Lipopolysaccharide MSD Musculoskeletal Disorders Organic Dusts Osteogenesis Toll-likereceptor4/TLR4

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• ISSN:
  1529-7322
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  16
• Volume:
  18
• Issue:
  3
• NIOSHTIC Number:
  nn:20051073
• Citation:
  Curr Allergy Asthma Rep 2018 Mar; 18(3):16
• Contact Point Address:
  Jill A. Poole, MD, Pulmonary, Critical Care, Sleep & Allergy Division; Department of Medicine, University of Nebraska Medical Center, 985990 Nebraska Medical Center, Omaha, NE 68198-5990, USA
• Email:
  japoole@unmc.edu
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Current Allergy & Asthma Reports
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73be7cdc9f8ab3aaddad5947598ac37c44f9ffea5d747526d1bb49bf030aed04484fd712c23754892bce640ef228c7d115c13bf549bb5fe51de56f609451a6f7
• Download URL:
  https://stacks.cdc.gov/view/cdc/211199/cdc_211199_DS1.pdf
• File Type:
  [PDF - 1.38 MB ]