In Vivo Measurement of Bone Manganese and Association with Manual Dexterity: A Pilot Study

Details

• Personal Author:
  Liu Y ; Mostafaei F ; Nie LH ; Rolle-McFarland D ; Wells EM ; Zheng W
• Description:
  We used neutron activation analysis (NAA) to measure hand bone manganese (BnMn) in 19 adult males. Median BnMn was 0.89 ug/g dry bone (interquartile range = 1.07). After adjustment for age and occupation, higher ln (BnMn) was significantly associated with lower manual dexterity based on the Purdue Pegboard assembly task: B = -1.77, standard error = 0.79, p = 0.04. Due to the small sample size, these results should be interpreted cautiously. BnMn appears to be a promising biomarker, and should be further studied. [Description provided by NIOSH]
• Subjects:
  Aging Behavior Biomarkers Environmental Exposure Manganese Men Nervous System Occupational Health Risk Assessment Risk Factors Safety

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• Keywords:
  Age Groups Author Keywords: Manganese Bone Structure Cognitive Function Dexterity Environmental Exposure Environmental Health Exposure Levels Health Effects Humans In Vivo Neutron Activation Analysis In Vivo Study IVNAA Motor Skills Neurotoxic Effects Neurotoxins Physiological Function Risk Factors

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; Louisiana ; Ohio ; OSHA Region 5 ; OSHA Region 6 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  35-38
• Volume:
  160
• NIOSHTIC Number:
  nn:20050906
• Citation:
  Environ Res 2018 Jan; 160:35-38
• Contact Point Address:
  Ellen M. Wells, School of Health Sciences, Purdue University, West Lafayette, IN 47907
• Email:
  wells54@purdue.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2018
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20140901
• Source Full Name:
  Environmental Research
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:164f6448b7b2446f8bb36d4404300100927344b0fa2a260817a3ce2a9fb465acc799c104bd642c304343840634fa82f1225d18126a22006847605c685c4556df
• Download URL:
  https://stacks.cdc.gov/view/cdc/211092/cdc_211092_DS1.pdf
• File Type:
  [PDF - 180.85 KB ]