Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone

Details

• Personal Author:
  Fu S ; Hong L ; Jiang W ; Jones A ; Nie LH ; O'Neal SL ; Zheng W
• Description:
  Literature data indicate that bone is a major storage organ for manganese (Mn), accounting for 43% of total body Mn. However, the kinetic nature of Mn in bone, especially the half-life (t(1/2)), remained unknown. This study was designed to understand the time-dependence of Mn distribution in rat bone after chronic oral exposure. Adult male rats received 50 mg Mn/kg (as MnCl2) by oral gavage, 5 days per week, for up to 10 weeks. Animals were sacrificed every 2 weeks during Mn administration for the uptake study, and on day 1, week 2, 4, 8, or 12 after the cessation at 6-week Mn exposure for the t(1/2) study. Mn concentrations in bone (MnBn) were determined by AAS analysis. By the end of 6-week's treatment, MnBn appeared to reach the steady state (T(ss)) level, about 2-3.2 fold higher than MnBn at day 0. Kinetic calculation revealed t(1/2)s of Mn in femur, tibia, and humerus bone of 77 (r=0.978), 263 (r=0.988), and 429 (r=0.994) days, respectively; the average t(1/2) in rat skeleton was about 143 days, equivalent to 8.5 years in human bone. Moreover, MnBn were correlated with Mn levels in striatum, hippocampus, and CSF. These data support MnBn to be a useful biomarker of Mn exposure. [Description provided by NIOSH]
• Subjects:
  Animals Biomarkers Environmental Exposure Hazardous Substances Laboratories Manganese Musculoskeletal System Nervous System Occupational Health Risk Assessment Risk Factors Safety

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• Keywords:
  Author Keywords: Manganese Biomarker Bone Bone-structure Disposition Environmental-exposure Exposure-levels Half-life Hazards Health-hazards Laboratory-animals Manganese-compounds Neurotoxicity Risk-factors Statistical-analysis

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• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  93-100
• Volume:
  229
• Issue:
  1
• NIOSHTIC Number:
  nn:20045034
• Citation:
  Toxicol Lett 2014 Aug; 229(1):93-100
• Contact Point Address:
  Wei Zheng, School of Health Science, Purdue University, 550 Stadium Mall Drive, CIVL 1173
• Email:
  wzheng@purdue.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2014
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  Toxicology Letters
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bea504f0e7c90c279100cd7f87c501a3f81638d5ca846b25fea10efb4c68b8311bdbe5cdf98f8380f0f874706bbafa18a1a34dca512ea0b5b3296df3a7a237cb
• Download URL:
  https://stacks.cdc.gov/view/cdc/200580/cdc_200580_DS1.pdf
• File Type:
  [PDF - 1.30 MB ]