Carcinogenicity of Benzene

Details

• Personal Author:
  Benbrahim-Tallaa L ; Bouvard V ; El Ghissassi F ; Grosse Y ; Guha N ; Guyton KZ ; Loomis D ; Mattock H ; Straif K ; Vilahur N
• Corporate Authors:
  World Health Organization. International Agency for Research on Cancer. Monograph Working Group
• Description:
  In October, 2017, a Working Group of 27 scientists from 13 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of benzene. Benzene, an aromatic hydrocarbon, is a ubiquitous air pollutant, arising mostly from anthropogenic sources, notably combustion. It is a component of gasoline, vehicle exhaust, industrial emissions, and tobacco smoke, and was used historically as a solvent in industry and consumer products. The uses of benzene as a solvent are now restricted in many countries, but it is still produced in high volumes for use primarily as a chemical intermediate. The Working Group focussed its review of epidemiological studies on those in which occupational or environmental exposure to benzene was specifically identified. Important new evidence came from several large occupational cohort studies. In adult humans, benzene causes acute non-lymphocytic leukaemia, including AML. The previous observations of limited evidence for chronic lymphocytic leukaemia, multiple myeloma, and non-Hodgkin lymphoma were also confirmed. New data were also available from several recent studies that showed positive associations between AML in children and environmental exposure to benzene. Positive associations with exposure to benzene were also observed for chronic myeloid leukaemia and for lung cancer in several studies. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Benzene Blood Carcinogens Chemistry Cohort Studies Environmental Exposure Epidemiology Hydrocarbons Occupational Exposure Occupational Health Safety

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• Keywords:
  Air Pollutants Aromatic Hydrocarbons Biological Effects Blood Cells Carcinogenicity Chemical Analysis Cohort Studies Combustion Products Environmental Exposure Health Effects Lymphocytes Myeloid Tissue Occupational Exposure Surveillance

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• ISSN:
  1470-2045
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  12
• NIOSHTIC Number:
  nn:20050671
• Citation:
  Lancet Oncol 2017 Dec; 18(12):1574-1575
• Contact Point Address:
  International Agency for Research on Cancer Monograph Working Group, International Agency for Research on Cancer, Lyon, France
• CAS Registry Number:
  Benzene (CAS RN 71-43-2)
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  The Lancet Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2b89eaff735af10f73304804fbec989ef32424f0da726f8f2443793440542a706b60dcd4846711f069056a963593c240697cedcd2d6bf7b4f4b19e7d2667ecf3
• Download URL:
  https://stacks.cdc.gov/view/cdc/210923/cdc_210923_DS1.pdf
• File Type:
  [PDF - 47.79 KB ]