Predictors of Polycyclic Aromatic Hydrocarbon Exposure and Internal Dose in Inner City Baltimore Children

Details

• Personal Author:
  Abubaker S ; Breysse PN ; Curtin-Brosnan J ; Diette GB ; Hansel NN ; Matsui EC ; McCormack MC ; Peng R ; Peters KO ; Strickland PT ; Williams DL
• Description:
  Polycyclic aromatic hydrocarbons (PAHs), the by-products of incomplete combustion of organic materials, are commonly found on particulate matter (PM) and have been associated with the development of asthma and asthma exacerbation in urban populations. We examined time spent in the home and outdoors as predictors of exposures to airborne PAHs and measured urinary 1-hydroxypyrene-glucuronide (1-OHPG) as internal dose of PAHs in 118 children aged 5-12 years from Baltimore, Maryland. During weeklong periods (Saturday-Saturday) in each of four seasons: daily activities were assessed using questionnaires, indoor air nicotine and PM concentrations were monitored, and urine specimens were collected on Tuesday (day 3) and Saturday (day 7) for measurement of 1-OHPG. Time spent in non-smoking homes was associated with significantly decreased 1-OHPG concentration in urine (β=-0.045, 95% CI (-0.076, -0.013)), and secondhand smoke (SHS) exposures modified these associations, with higher urinary 1-OHPG concentrations in children spending time in smoking homes than non-smoking homes (P-value for interaction=0.012). Time spent outdoors was associated with increased urinary 1-OHPG concentrations (β=0.097, 95% CI (0.037, 0.157)) in boys only. Our results suggest that SHS and ambient (outdoor) air pollution contribute to internal dose of PAHs in inner city children. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Air Pollution, Indoor Environmental Exposure Hydrocarbons Nicotine Occupational Health Particulate Matter Polycyclic Aromatic Hydrocarbons Safety Smokers Surveys And Questionnaires Urine

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• Keywords:
  1-hydroxypyrene-glucuronide Airborne Particulates Air Contaminants Air Pollutants Air Pollution Author Keywords: Polycyclic Aromatic Hydrocarbons Children Cigarette Smoke Environmental Exposure Exposure Assessment Humans Indoor Air Pollution Outdoors Particulates Polycyclic Aromatic Hydrocarbons Questionnaires Secondhand Smoke Smoking Urinalysis

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• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  290-298
• Volume:
  27
• Issue:
  3
• NIOSHTIC Number:
  nn:20050538
• Citation:
  J Expo Sci Environ Epidemiol 2017 May; 27(3):290-298
• Contact Point Address:
  Dr. Kamau O. Peters, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E528, Rockville, MD 20850, USA
• Email:
  kamau.peters@nih.gov
• CAS Registry Number:
  (-)-Nicotine (CAS RN 54-11-5)
• Federal Fiscal Year:
  2017
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6a0dcd62db0e40e70be1baf46741756b29b597db245208368376ca2f6da2d354bc6383b65123792d35a580389ce5b7d67ce4e9a71b11b0994054a7d7d9074e6d
• Download URL:
  https://stacks.cdc.gov/view/cdc/210845/cdc_210845_DS1.pdf
• File Type:
  [PDF - 309.02 KB ]