Sex Differences in Sensitivity to Prenatal and Early Childhood Manganese Exposure on Neuromotor Function in Adolescents

Details

• Personal Author:
  Arora M ; Austin C ; Cagna G ; Chiu Y-HM ; Claus Henn BC ; Coull BA ; Fedrighi C ; Hsu H-HL ; Lucchini RG ; Pendo MP ; Placidi D ; Smith DR ; Wright RO
• Description:
  INTRODUCTION: While studies have suggested that exposure to manganese (Mn) may be associated with neurodevelopment in school-age children, there is limited information on prenatal and postnatal Mn exposures and tremor or motor function in children. METHODS: We measured Mn levels in dentine of shed teeth, representing prenatal, early postnatal, and cumulative childhood exposure windows, from 195 children (predominantly right-handed, 92%) in Italy. Pursuit Aiming, Luria Nebraska Motor Battery, as well as Tremor and Sway system from Computerized Adaptive Testing System (CATSYS) were administered at 11-14 years old. We examined the relationships of tooth Mn (ln-transformed) with motor function using multivariable linear regressions and generalized additive models, adjusting for age, sex, and socioeconomic status index. Effect modification by sex was also examined. RESULTS: We found that higher prenatal Mn was associated with better body stability in boys in a number of sway tests (including mean sway, transversal sway, sagittal sway, sway area, and sway intensity), while Mn was associated with poorer performance in girls on all of these metrics (all p for Mn × sex interaction < 0.05). Higher prenatal Mn was also modestly associated with better hand/finger and eye-hand coordination in boys compared to girls in sex-stratified analyses, although interaction models did not reach statistical significance. For tremor, on the other hand, higher early postnatal Mn was associated with increased right-hand center frequency in girls (p for interaction < 0.01), but increased Mn level at the later postnatal period was associated with increased center frequency in boys (p for interaction = 0.01). CONCLUSIONS: This study, which used a direct measure of prenatal and childhood Mn exposure, suggested sex-specific critical windows of early life Mn exposure in relation to neuromotor function in adolescents. The sex-specific associations might be strongest with measures of whole body stability, for which the critical exposure window was during the prenatal period. [Description provided by NIOSH]
• Subjects:
  Adolescent Biomarkers Chemistry Environmental Exposure Hazardous Substances Manganese Men Occupational Health Pregnancy Risk Assessment Risk Factors Safety Women

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• Keywords:
  Adolescents Author Keywords: Adolescents Chemical Properties Children Drugs Exposure Levels Health Effects Humans Manganese Compounds Motor Function Nervous System Neurological System Pollutants Prenatal And Postnatal Exposure Prenatal Exposure Risk Factors Sex Difference Tooth Biomarker Toxins

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 9 ; Tennessee
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  458-465
• Volume:
  159
• NIOSHTIC Number:
  nn:20050495
• Citation:
  Environ Res 2017 Nov; 159:458-465
• Contact Point Address:
  Yueh-Hsiu Mathilda Chiu, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029
• Email:
  mathilda.chiu@mssm.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2018
• Performing Organization:
  Mount Sinai School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:050f7534398053b6001297472b393a74484bff32d86087797cba92145ba3bf705ace70f0f75765855a56289e77aa63468c6749b3c36075855806257d7f6cad94
• Download URL:
  https://stacks.cdc.gov/view/cdc/210814/cdc_210814_DS1.pdf
• File Type:
  [PDF - 236.30 KB ]