Association of Maternal Blood Manganese Levels and Infant Birth Weight

Details

• Personal Author:
  Amarasiriwardena CJ ; Bouchard M ; Ettinger AS ; Hu H ; Schwartz J ; Wright RO ; Zota A
• Description:
  BACKGROUND: Manganese is both an essential element and a known neurotoxicant to children. High manganese exposures have been associated with negative reproductive outcomes in animals, but few epidemiologic studies have examined the effects of human fetal manganese exposure. METHODS: We studied the association between maternal and umbilical cord blood manganese levels and birth weight in a cohort of 470 mother-infant pairs born at term (>or=37 weeks gestation) in Ottawa County, Oklahoma. Nonlinear spline and quadratic regression models were used to test the hypothesis of an inverted U-shaped relationship between manganese levels and birth weight. RESULTS: Mean (standard deviation) concentration of manganese was 2.4 (0.95) microg/dL in the maternal blood and 4.2 (1.6) microg/dL in the cord blood. Umbilical cord manganese was not associated with birth weight. A nonlinear relationship was observed between maternal manganese and birth weight after adjusting for potential confounders. Birth weight increased with manganese levels up to 3.1 microg/L, and then a slight reduction in weight was observed at higher levels. Compared with the 3.1-microg/L point of inflection, birth weight estimates at the 5th (1.3 microg/L) and 95th (4.0 microg/L) percentiles of exposure were -160 g (95% confidence interval = -286 to -33) and -46 g (-38 to 131), respectively. CONCLUSIONS: Maternal blood manganese levels during pregnancy are associated with birth weight in a nonlinear pattern in full-term infants. These findings suggest that manganese may affect fetal growth. Possible detrimental effects of elevated manganese levels on the fetus should be further examined in more highly exposed populations. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Exposure Laboratories Manganese Men Nervous System Occupational Health Pregnancy Risk Assessment Risk Factors Safety Urogenital System Women

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• Keywords:
  Exposure Levels Humans Laboratory Animals Models Neurotoxic Agents Neurotoxic Effects Prenatal Exposure Reproductive Effects Reproductive Hazards Reproductive Health Risk Factors

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• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  367-373
• Volume:
  20
• Issue:
  3
• NIOSHTIC Number:
  nn:20054301
• Citation:
  Epidemiology 2009 May; 20(3):367-373
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2009
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:96caa5422224f772b98240296ca977b57454fea0e11db2eb5ec4bfe9ee94b9c19f271e484637f12668b57d52634517b8d09c38f8eaeb63877a8807487d0ae07e
• Download URL:
  https://stacks.cdc.gov/view/cdc/216893/cdc_216893_DS1.pdf
• File Type:
  [PDF - 352.83 KB ]