Ozone Exposure, Cardiopulmonary Health, and Obesity: A Substantive Review

Details

• Personal Author:
  Koman PD ; Mancuso P
• Description:
  From 1999-2014, obesity prevalence increased among adults and youth. Obese individuals may be uniquely susceptible to the proinflammatory effects of ozone because obese humans and animals have been shown to experience a greater decline in lung function than normal-weight subjects. Obesity is independently associated with limitations in lung mechanics with increased ozone dose. However, few epidemiologic studies have examined the interaction between excess weight and ozone exposure among adults. Using PubMed keyword searches and reference lists, we reviewed epidemiologic evidence to identify potential response-modifying factors and determine if obese or overweight adults are at increased risk of ozone-related health effects. We initially identified 170 studies, of which seven studies met the criteria of examining the interaction of excess weight and ozone exposure on cardiopulmonary outcomes in adults, including four short-term ozone exposure studies in controlled laboratory settings and three community epidemiologic studies. In the studies identified, obesity was associated with decreased lung function and increased inflammatory mediators. Results were inconclusive about the effect modification when data were stratified by sex. Obese and overweight populations should be considered as candidate at-risk groups for epidemiologic studies of cardiopulmonary health related to air pollution exposures. Air pollution is a modifiable risk factor that may decrease lung function among obese individuals with implications for environmental and occupational health policy. [Description provided by NIOSH]
• Subjects:
  Air Pollution Environmental Exposure Epidemiology Immune System Lung Occupational Health Ozone Public Health Respiratory System Risk Assessment Risk Factors Safety

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• Keywords:
  Air Pollution Cardiopulmonary Function Cardiopulmonary System Cardiopulmonary System Disorders Environmental Exposure Environmental Health Health Effects Humans Immune Reaction Lung Function Obesity Public Health Risk Factors Systematic Reviews Weight Factors

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• ISSN:
  0893-228X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  30
• Issue:
  7
• NIOSHTIC Number:
  nn:20050477
• Citation:
  Chem Res Toxicol 2017 Jul; 30(7):1384-1395
• Contact Point Address:
  Patricia D. Koman, Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, United States
• Email:
  tkoman@umich.edu
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Chemical Research in Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:24cbc3f344666520504fcb69858c8b6966dfedb41f4f3aaddc486e193041ac2fb9c4daaeb054a98cecda698afdf6cfe4cedce0648a3b5f34bcfefa526fc23aae
• Download URL:
  https://stacks.cdc.gov/view/cdc/210802/cdc_210802_DS1.pdf
• File Type:
  [PDF - 1.42 MB ]