Systematic review of ozone effects on human lung function, 2013 through 2020.

Details

• Personal Author:
  Balmes JR ; Holm SM
• Description:
  Background: Ozone effects on lung function are particularly important to understand in the context of the air pollution-health outcomes epidemiologic literature, given the complex relationships between ozone and other air pollutants with known lung function effects. Research Question: What has been learned about the association between ozone exposures and lung function from epidemiology studies published from 2013 through 2020? Study Design and Methods: On March 18, 2018, and September 8, 2020, PubMed was searched using the terms health AND ozone, filtering to articles in English and about humans, from 2013 or later. An additional focused review searching for ozone AND (lung function OR FEV1 OR FVC) was performed June 26, 2021. Articles were selected for this review if they reported a specific relationship between a lung function outcome and ozone exposure. Results: Of 3,271 articles screened, 53 ultimately met criteria for inclusion. A systematic review with assessment of potential for bias was conducted, but a meta-analysis was not carried out because of differences in exposure duration and outcome quantification. Consistent evidence exists of small decreases in children's lung function, even associated with very low levels of short-term ozone exposure. The effects on adult lung function from exposure to low-level, short-term ozone are less clear, although ozone-associated decrements may occur in the elderly. Finally, long-term ozone exposure decreases both lung function and lung function growth in children, although few new studies have examined long-term ozone and lung function in adults. Interpretation: Much of this literature involves concentrations below the current US Environmental Protection Agency's National Ambient Air Quality Standard of 70 parts per billion over an 8-h averaging time, suggesting that this current standard may not protect children adequately from ozone-related decrements in lung function. [Description provided by NIOSH]
• Subjects:
  Aging Air Pollution Epidemiology Lung Occupational Health Ozone Respiratory System Safety
• Keywords:
  Author Keywords: Adult; Air Pollution; Child; Epidemiology; Spirometry Lung Function; Ozone; Air Pollution; Epidemiology; Systematic Reviews; Age Groups; Air Quality Control; Respiratory Function;
• ISSN:
  0012-3692
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  190-201
• Volume:
  161
• Issue:
  1
• NIOSHTIC Number:
  nn:20065559
• Citation:
  Chest 2022 Jan; 161(1):190-201
• Contact Point Address:
  Stephanie M. Holm MD, PhD, MPH, Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA
• Email:
  stephanie.holm@ucsf.edu
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Chest
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5563a0f1807c44277ee75eb1e61c58426313ac2940017400272693fd038ca57ba0b1abf47aaa4a44a74c3c572ea6466bffd8b3a641855e5caa41e25bcdd70cc4
• Download URL:
  https://stacks.cdc.gov/view/cdc/249476/cdc_249476_DS1.pdf
• File Type:
  [PDF - 776.08 KB ]