Effects of short-term increases in personal and ambient pollutant concentrations on pulmonary and cardiovascular function: a panel study analysis of the Multicenter Ozone Study in oldEr subjects (MOSES 2).

Details

• Personal Author:
  Alexis NE ; Arjomandi M ; Balmes JR ; Bromberg PA ; Frampton MW ; Ganz P ; Hazucha MJ ; Koutrakis P ; Rich DQ ; Thevenet-Morrison K ; Thurston SW ; Zareba W
• Description:
  Background: The cardiovascular effects of ozone exposure are unclear. Using measurements from the 87 participants in the Multicenter Ozone Study of oldEr Subjects (MOSES), we examined whether personal and ambient pollutant exposures before the controlled exposure sessions would be associated with adverse changes in pulmonary and cardiovascular function. Methods: We used mixed effects linear regression to evaluate associations between increased personal exposures and ambient pollutant concentrations in the 96 h before the pre-exposure visit, and 1) biomarkers measured at pre-exposure, and 2) changes in biomarkers from pre-to post-exposure. Results: Decreases in pre-exposure forced expiratory volume in 1s (FEV1) were associated with interquartile-range increases in concentrations of particulate matter ≤2.5 µm (PM2.5) 1 h before the pre-exposure visit (-0.022 L; 95% CI -0.037 to -0.006; p = 0.007), carbon monoxide (CO) in the prior 3 h (-0.046 L; 95% CI -0.076 to -0.016; p = 0.003), and nitrogen dioxide (NO2) in the prior 72 h (-0.030 L; 95% CI -0.052 to -0.008; p = 0.007). From pre-to post-exposure, increases in FEV1 were marginally significantly associated with increases in personal ozone exposure (0.010 L; 95% CI 0.004 to 0.026; p = 0.010), and ambient PM2.5 and CO at all lag times. Ambient ozone concentrations in the prior 96 h were associated with both decreased pre-exposure high frequency (HF) heart rate variability (HRV) and increases in HF HRV from pre-to post-exposure. Conclusions: We observed associations between increased ambient PM2.5, NO2, and CO levels and reduced pulmonary function, and increased ambient ozone concentrations and reduced HRV. Pulmonary function and HRV increased across the exposure sessions in association with these same pollutant increases, suggesting a "recovery" during the exposure sessions. These findings support an association between short term increases in ambient PM2.5, NO2, and CO and decreased pulmonary function, and increased ambient ozone and decreased HRV. [Description provided by NIOSH]
• Subjects:
  Air Pollution Biomarkers Carbon Monoxide Environmental Exposure Environmental Pollution Hazardous Substances Lung Lung Diseases Men Nitrogen Dioxide Occupational Health Ozone Particulate Matter Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Women

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• Keywords:
  Author Keywords: Air Pollution; Cardiovascular; Health Effects; Human; Ozone; Pulmonary Function Exposure Levels; Risk Factors; Pollutants; Pollution; Pulmonary System Disorders; Respiratory System Disorders; Cardiovascular Function; Ozone; Humans; Men; Women; Biomarkers; Particulates; Carbon Monoxide; Nitrogen Dioxide; Toxins; Health Effects; Air Pollution; Environmental Exposure; Environmental Pollution;
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  205
• NIOSHTIC Number:
  nn:20064875
• Citation:
  Environ Res 2022 Apr; 205:112522
• Contact Point Address:
  Mark W. Frampton, Professor Emeritus of Medicine, University of Rochester Medical Center, Pulmonary and Critical Care, 601 Elmwood Avenue, Box 692, Rochester, NY, 14642-8692
• Email:
  mark_frampton@urmc.rochester.edu
• CAS Registry Number:
  Carbon monoxide (CAS RN 630-08-0) ; Nitrogen dioxide (CAS RN 10102-44-0) ; Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f4c42cceac376cc7d27beca7b4e61afdb3c5cd752fca017eeeb0f8485ecd5b7ceb3df45011a7a2ec6f5f9b94fb37e9aac6b4b5841bc953abbbd6882bcdfc7062
• Download URL:
  https://stacks.cdc.gov/view/cdc/249259/cdc_249259_DS1.pdf
• File Type:
  [PDF - 3.07 MB ]