Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics

Details

• Alternative Title:
  Cancer Epidemiol
• Personal Author:
  Hall, Clinton ; Ritz, Beate ; Cockburn, Myles ; Davidson, Tom B. ; Heck, Julia E.
• Description:
  Background ; Childhood germ cell tumors (GCTs) are a rare assortment of neoplasms, with mostly unknown etiology, that are believed to originate very early in life. Few studies have examined risk factors by histologic subtype, despite evidence of different risk profiles. ; Materials and Methods ; In this population-based case-control study, 451 childhood malignant GCT cases ages 0–5 years were identified from the California Cancer Registry. Differentiating between common histologic subtypes, we identified 181 yolk sac tumors, 216 teratomas, and 54 rarer subtypes. Cases were linked to their birth certificates and 271,381 controls, frequency matched by birth year, were randomly selected from California birthrolls to investigate the contributions of demographic, gestational, and pregnancy factors using unconditional logistic regression analysis. ; Results ; Compared to non-Hispanic whites, Asian/Pacific Islander children were at an increased risk for developing GCTs (odds ratio OR=1.94; 95% confidence interval CI=1.47, 2.56). Among pregnancy complications and procedures, yolk sac tumors were positively associated with the presence of fetopelvic disproportion (OR=2.97; 95% CI=1.55, 5.68), while teratomas were strongly associated with polyhydramnios or oligohydramnios (OR=14.76; 95% CI=7.21, 30.19) and the presence of an ear, face, or neck anomaly at birth (OR=93.70; 95% CI=42.14, 208.82). ; Conclusions ; Malignant yolk sac tumors and malignant teratomas exhibited distinct demographic and gestational characteristics; additionally, complications in pregnancy and labor may be brought on by specific histologic subtypes.
• Keywords:
  • germ cell tumor
  • yolk sac tumor
  • teratoma
  • childhood
  • cancer
  • congenital malformation
  • race
  • perinatal
  • risk factor
  • epidemiology
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• Source:
  Cancer Epidemiol. 46:42-49
• Pubmed ID:
  28013088
• Pubmed Central ID:
  PMC5272784
• Document Type:
  Journal Article
• Funding:
  HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; UL1 TR000124/TR/NCATS NIH HHSUnited States/ ; T42 OH008412/OH/NIOSH CDC HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR001881/TR/NCATS NIH HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; R21 CA175959/CA/NCI NIH HHSUnited States/ ; R21 ES018960/ES/NIEHS NIH HHSUnited States/ ; R03 ES021643/ES/NIEHS NIH HHSUnited States/ ; T42OH008412/ACL/ACL HHSUnited States/ ; R21 ES019986/ES/NIEHS NIH HHSUnited States/
  More +
• Volume:
  46
• Download URL:
  https://stacks.cdc.gov/view/cdc/43986/cdc_43986_DS1.pdf
• File Type:
  [PDF - 380.49 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f4f01c3b069d96696c5ea26eb989827adb151e141debd6d79e7018226450e85f