In Vivo Toxicity Assessment of Occupational Components of the Carbon Nanotube Life Cycle to Provide Context to Potential Health Effects

Details

• Personal Author:
  Afshari A ; Battelli L ; Birch, M. Eileen ; Bishop L ; Bunker K ; Casuccio G ; Cena L ; Dahm, Matthew M. ; Erdely A ; Evans DE ; Eye T ; Friend S ; Geraci, Charles L. ; Kang J ; Kashon ML ; Kodali VK ; Lersch TL ; Lowry DT ; Lupoi JS ; Mercer RR ; Mitchell CA ; Orandle M ; Sager T ; Sargent LM ; Schubauer-Berigan, Mary K. ; Schwegler-Berry D ; Siegrist KJ ; Stefaniak, Aleksandr B. ; Yanamala N ; Zeidler-Erdely PC
• Description:
  Pulmonary toxicity studies on carbon nanotubes focus primarily on as-produced materials and rarely are guided by a life cycle perspective or integration with exposure assessment. Understanding toxicity beyond the asproduced, or pure native material, is critical, due to modifications needed to overcome barriers to commercialization of applications. In the first series of studies, the toxicity of as-produced carbon nanotubes and their polymer-coated counterparts was evaluated in reference to exposure assessment, material characterization, and stability of the polymer coating in biological fluids. The second series of studies examined the toxicity of aerosols generated from sanding polymer-coated carbon-nanotube-embedded or neat composites. Postproduction modification by polymer coating did not enhance pulmonary injury, inflammation, and pathology or in vitro genotoxicity of as-produced carbon nanotubes, and for a particular coating, toxicity was significantly attenuated. The aerosols generated from sanding composites embedded with polymer-coated carbon nanotubes contained no evidence of free nanotubes. The percent weight incorporation of polymer-coated carbon nanotubes, 0.15% or 3% by mass, and composite matrix utilized altered the particle size distribution and, in certain circumstances, influenced acute in vivo toxicity. Our study provides perspective that, while the number of workers and consumers increases along the life cycle, toxicity and/or potential for exposure to the as-produced material may greatly diminish. [Description provided by NIOSH]
• Subjects:
  Aerosols Immune System Laboratories Lung Occupational Health Particulate Matter Polymers Respiratory System Safety Toxicology
• Keywords:
  Author Keywords: Life Cycle Carbon Nanotubes Coatings Composite Exposure Assessment Genotoxicity Immune Reaction In Vivo Study Laboratory Animals Nanotoxicology Particle Size Polymer Coating Pulmonary Effects Toxicity

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• ISSN:
  1936-0851
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology ; RHD - Respiratory Health Division ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• Issue:
  9
• NIOSHTIC Number:
  nn:20050202
• Citation:
  ACS Nano 2017 Sep; 11(9):8849-8863
• Contact Point Address:
  Aaron Erdely, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, United States
• Email:
  efi4@cdc.gov
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  ACS Nano
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0781b17daa39bbf083c2794167a52a46704eceaed36f8b1e2a5b3c3c520ec4fbedb84a05ac85a20789b4ce7ca9b4ac36b95180f5622108447efcb43707caa153
• Download URL:
  https://stacks.cdc.gov/view/cdc/210650/cdc_210650_DS1.pdf
• File Type:
  [PDF - 907.95 KB ]