Utility of Lung Clearance Index Testing as a Noninvasive Marker of Deployment-Related Lung Disease

Details

• Personal Author:
  Krefft SD ; Meehan R ; Rose C ; Smith J ; Strand M ; Stroup C
• Description:
  Objective: The aim of this study was to determine utility and sensitivity of lung clearance index (LCI) testing as a marker of lung injury in symptomatic military deployers compared with healthy controls. Methods: We tested 24 healthy controls and 28 deployers with respiratory symptoms (17 of 28 with definite and 11 of 28 with probable deployment-related lung disease). We compared mean LCI scores between deployers and controls using t tests; adjusted tests were derived from multiple regression models. Results: Mean LCI scores were significantly higher (P=0.001) in deployers [7.76, 95% confidence interval (95% CI) 7.34 to 8.17] than controls (6.95, 95% CI 6.73 to 7.17). Adjusting for body mass index (BMI), smoking, and age, there were no significant differences (P¼0.10) between mean LCI scores in deployers (7.42, 95% CI 7.13 to 7.71) and controls (7.06, 95% CI 6.74 to 7.39). Conclusions: The trend toward higher LCI scores in symptomatic deployers may be linked to underlying lung disease and/or BMI but requires further investigation in a larger population. [Description provided by NIOSH]
• Subjects:
  Aging Lung Lung Diseases Men Occupational Health Respiratory System Respiratory Tract Diseases Safety Smokers Women
• Keywords:
  Age Groups BMI Body Mass Index Humans Lung Disease Lung Disorders Military Personnel Models Pulmonary System Pulmonary System Disorders Respiratory System Disorders Smoking Statistical Analysis

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  8
• NIOSHTIC Number:
  nn:20050195
• Citation:
  J Occup Environ Med 2017 Aug; 59(8):707-711
• Contact Point Address:
  Silpa Dhoma Krefft, MD, MPH, 1400 Jackson Street, DEOHS-G208, Denver, CO 80206
• Email:
  KrefftS@NJHealth.org
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Colorado, Denver
• Peer Reviewed:
  True
• Start Date:
  20070701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:56b2b24bffeff0df9c6ed8d74b85c317fe220e623b052f5fbf3844334e071c1a1439d83674bacefc988c6cbd50b6b442d9f1985ac8c3069a19e33ab148baec6c
• Download URL:
  https://stacks.cdc.gov/view/cdc/210646/cdc_210646_DS1.pdf
• File Type:
  [PDF - 120.63 KB ]