Association between polymorphisms in the microsomal epoxide hydrolase (mEH) gene and chronic obstructive pulmonary disease

Details

• Personal Author:
  Christiani, David C. ; Du M-j ; Liu J-z ; Pang B-s ; Su L ; Wang C ; Weng X-z ; Xiao B ; Xiao D ; Zhang H-y
• Description:
  Objective: To investigate the association between polymorphisms in the microsomal epoxide hydrolase (mEH) gene and susceptibility to chronic obstructive pulmonary disease (COPD) in a Chinese population. Methods: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to genotype mEH polymorphisms in exon3 (Tyr113-->His) and exon4 (His139-->Arg) in 100 COPD patients and 100 age and sex matched healthy controls. Results: (1) The proportion of mEH heterozygotes in exon3 was significantly higher in the patients with COPD than that in the control subjects (42% vs 32%). The odds ratio (OR) adjusted by age, sex, body mass index (BMI) and cigarettes years was 2.96 (95% CI 1.24 - 7.09). (2) There was no marked difference in very slow activity genotype versus other genotypes between COPD patients and controls. (3) When COPD patients were nonsmokers, the OR of very slow activity genotype versus other genotypes was more than 1.00, and when COPD patients were smokers (Current smokers and ex-smokers), the OR was less than 1.00. Conclusions: (1) mEH heterozygotes in exon3 might be associated with the susceptibility to COPD in China. (2) The interaction might be existed between mEH genotype and smoke. [Description provided by NIOSH]
• Subjects:
  Aging Energy Metabolism Genetics Lung Diseases Men Occupational Health Respiratory Tract Diseases Safety Smokers Tobacco Products Women

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• Keywords:
  Author Keywords: Obstructive Lung Diseases; Microsomes; Epoxide Hydrolases Genes; Smoking Genes; COPD; Chronic Obstructive Pulmonary Disease; Humans; Men; Women; Age Groups; Statistical Analysis; Genotype; Cigarette Smoking; Respiratory System Disorders; Pulmonary System Disorders; Smoking; Metabolism;
• ISSN:
  0376-2491
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  83
• Issue:
  20
• NIOSHTIC Number:
  nn:20059955
• Citation:
  Zhonghua Yixue Zazhi 2003 Oct; 83(20):1782-1786
• Contact Point Address:
  Dan Xiao, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital Affiliated Capital University of Medical Sciences, Beijing 100020, China
• Federal Fiscal Year:
  2004
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030701
• Source Full Name:
  Zhonghua Yixue Zazhi
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6717bb51a67a7261a35cbcecd2e2640d889ffd5b8e4242e6efc704c2ea13553368d4dd8f5c4b1be470aa665c0c55d746b711724a4d5b6f8a614664aa5e4e64f1
• Download URL:
  https://stacks.cdc.gov/view/cdc/229338/cdc_229338_DS1.pdf
• File Type:
  [PDF - 3.49 MB ]