The relationship between glutathione S-transferase P1 and chronic obstructive pulmonary disease

Details

• Personal Author:
  Christiani, David C. ; Du M-j ; Liu J-z ; Pang B-s ; Su L ; Wang C ; Weng X-z ; Xiao B ; Xiao D ; Zhang H-y
• Description:
  Objective: To investigate the association between polymorphisms in the gene coding for glutathione S-transferase P1 (GSTP1) and susceptibility to chronic obstructive pulmonary disease (COPD) in a Chinese population. Methods: This was a pilot study of the molecular epidemiology in patients with COPD. The research design was a case-control study. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to genotype GSTP1 polymorphisms in exon 5 in 100 COPD patients and 100 age and sex matched healthy controls. Logistic regression analysis method was used to calculate the odds ratio (OR) and the 95% confidence interval (CI). Result: There was no significant difference in GSTP1 polymorphisms adjusted by age, sex, body mass index and smoking between COPD patients and controls. Conclusion: The gene polymorphism for GSTP1 was not associated with susceptibility to COPD in the Chinese population. [Description provided by NIOSH]
• Subjects:
  Aging Energy Metabolism Epidemiology Genetics Lung Diseases Men Occupational Health Respiratory Tract Diseases Safety Women
• Keywords:
  Genes; COPD; Chronic obstructive pulmonary disease; Humans; Men; Women; Age groups; Statistical analysis; Genotype; Respiratory system disorders; Pulmonary system disorders; Metabolism; Molecular epidemiology; Epidemiology; Case control studies; Body Mass Index; BMI
• ISSN:
  1001-0939
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  9
• NIOSHTIC Number:
  nn:20059956
• Citation:
  Zhonghua Jiehe he Huxi Zazhi 2003 Sep; 26(9):555-558
• Contact Point Address:
  Dan Xiao, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital Affiliated Capital University of Medical Sciences, Beijing 100020, China
• CAS Registry Number:
  Glutathione (CAS RN 70-18-8)
• Federal Fiscal Year:
  2003
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  False
• Start Date:
  20030701
• Source Full Name:
  Zhonghua Jiehe he Huxi Zazhi
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e918fb67ab0354248a43775e0f303f49044f3e1d3644d58f05ac663ad0e21b26c31442e914736e0eb8e187ad3cda6f9dbd7ea0ace4e395d921158cb87f2cd2c
• Download URL:
  https://stacks.cdc.gov/view/cdc/229868/cdc_229868_DS1.pdf
• File Type:
  [PDF - 179.27 KB ]