Ambient Size Distributions and Lung Deposition of Aerosol Dithiothreitol-Measured Oxidative Potential: Contrast Between Soluble and Insoluble Particles

Details

• Personal Author:
  Fang T ; Gao D ; Stefaniak, Aleksandr B. ; Verma V ; Weber RJ ; Zeng L
• Description:
  Ambient particulate matter may upset redox homeostasis, leading to oxidative stress and adverse health effects. Size distributions of water-insoluble and water-soluble OPDTT(dithiothreitol assay, measure of oxidative potential per air volume) are reported for a roadside site and an urban site. The average water-insoluble fractions were 23% and 51%, and 37% and 39%, for fine and coarse modes at the roadside and urban sites, respectively, measured during different periods. Water-soluble OPDTTwas unimodal, peaked near 1-2.5 µm due to contributions from fine-mode organic components plus coarse-mode transition metal ions. In contrast, water-insoluble OPDTTwas bimodal, with both fine and coarse modes. The main chemical components that drive both fractions appear to be the same, except that for water-insoluble OPDTTthe compounds were absorbed on surfaces of soot and non-tailpipe traffic dust. They were largely externally mixed and deposited in different regions in the respiratory system, transition metal ions predominately in the upper regions and organic species, such as quinones, deeper in the lung. Although OPDTTper mass (toxicity) was highest for ultrafine particles, estimated lung deposition was mainly from accumulation and coarse particles. Contrasts in the phases of these forms of OPDTTdeposited in the respiratory system may have differing health impacts. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Environmental Exposure Environmental Pollution Occupational Health Oxidants Particulate Matter Safety
• Keywords:
  Airborne Particulates Air Pollutants Chemical Deposition Environmental Pollution Oxidative Processes Oxidative Stress Particle Size
• ISSN:
  0013-936X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Illinois ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  51
• Issue:
  12
• NIOSHTIC Number:
  nn:20050066
• Citation:
  Environ Sci Technol 2017 Jun; 51(12):6802-6811
• Contact Point Address:
  Rodney J. Weber, School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States
• Email:
  rodney.weber@eas.gatech.edu
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Healthcare and Social Assistance ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Science and Technology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:515d4440421ca442333921fe59f52edb9070c8eab4f88c1a36e2c09b1ac71b67fcae5aeb2f077163f83d0b9145b5799a786090d10b9d3443d3df29003ccc5eb0
• Download URL:
  https://stacks.cdc.gov/view/cdc/210583/cdc_210583_DS1.pdf
• File Type:
  [PDF - 3.41 MB ]