A Review of High Performance Liquid Chromatographic-Mass Spectrometric Urinary Methods for Anticancer Drug Exposure of Health Care Workers

Details

• Personal Author:
  B'Hymer, Clayton ; Connor, Thomas H. ; Mathias PI
• Description:
  This review describes published high performance liquid chromatography/mass spectrometry (HPLC-MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC-MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC-MS methods are presented, as well as future trends and limitations in this area of research. [Description provided by NIOSH]
• Subjects:
  Biomarkers Body Fluids Chemistry Chromatography Drug Therapy Laboratories Mass Spectrometry Neoplasms Occupational Health Safety Urine

  More +
• Keywords:
  Analytical Methods Anticancer Drugs Antineoplastic Agents Antineoplastic Drug Author Keywords: Liquid Chromatography Mass Spectrometry Biomonitoring Body Fluids Cancer Chemical-analysis Chromatographic-analysis Cytotoxins Drugs Drug Therapy Health Care Laboratory-equipment Laboratory-techniques Liquid-chromatography Mass-spectrometry Occupational Biomonitoring Oncogenic Agents Quantitative-analysis Systematic Reviews Urinalysis Urinary Biomarker

  More +
• ISSN:
  1570-0232
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  316-324
• Volume:
  1060
• NIOSHTIC Number:
  nn:20050012
• Citation:
  J Chromatogr B 2017 Aug; 1060:316-324
• Contact Point Address:
  Patricia I. Mathias, National Institute for Occupational Safety and Health, Divisionof Applied Science and Technology, Biomonitoring and Health Assessment Branch, Robert A. Taft Laboratories, 1150 Tusculum Avenue, Cincinnati, OH 45226, United States
• Email:
  pmathias@cdc.gov
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:49e48f38c71c929915befe5e6a6035e8cd4c01d0f6045ff59baf02159fe2e5770dc682ed2640b1bec523386fcc00100cf8fb04ec225b1d4b12bcb2e20c36ee1f
• Download URL:
  https://stacks.cdc.gov/view/cdc/210567/cdc_210567_DS1.pdf
• File Type:
  [PDF - 564.71 KB ]