Ca2+ and Respiratory Smooth Muscle Function: Is There a Role for Calcium Entry Blockers in Asthma Therapy?

Details

• Personal Author:
  Fedan, Jeffery S. ; Hay DWP ; Raeburn D
• Description:
  The purpose of this chapter is to discuss the actions of Ca2+ entry blocking drugs (CEBs)-also variously referred to as Cal+ antagonists, Ca2+ channel blockers, and Ca2+ channel inhibitors - on the respiratory smooth muscle of experimental animals and humans in vitro and in vivo. An overview of the role ofCa2+ in excitation-contraction coupling mechanisms in respiratory smooth muscle will first be presented, as research in this area is only recently developing, and there are some differences between the effects of CEBs on airways and other smooth muscles. In light of recent interest in CEBs as drugs for treating bronchoconstrictive disorders, the potential therapeutic role of this class of drugs in the treatment and/or prophylaxis of asthma and other respiratory disorders will be discussed. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Musculoskeletal System Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal Studies Humans In Vitro Study In Vivo Study Laboratory Animals Muscle Function Pharmacodynamics Pharmacology Respiratory Function Respiratory System Disorders
• ISBN:
  9780444012531
• ISSN:
  0890-1449
• Publisher:
  Elsevier
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  53-94
• Volume:
  3
• NIOSHTIC Number:
  nn:20049831
• Citation:
  Current topics in pulmonary pharmacology and toxicology. Hollinger MA, ed. New York: Elsevier, 1987 Jan; 3:53-94
• Editor(s):
  Hollinger MA
• Federal Fiscal Year:
  1987
• Peer Reviewed:
  False
• Source Full Name:
  Current topics in pulmonary pharmacology and toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e0b7188240a669fadfecf1c63d88fa8289b5fcd54bf651aef278579d73b5ea24f6706b995859ed5a1f65c52acdbd9669698cc8177a6de0450d0539c113a081a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/210451/cdc_210451_DS1.pdf
• File Type:
  [PDF - 15.78 MB ]