Pulmonary response to inhaled fibrogenic minerals.

Details

• Personal Author:
  Vallyathan V
• Description:
  The purpose for this study was to determine the fibrogenicity of silica (7631869), bentonite (1302789), kaolin (1332587), talc (14807966), vermiculite (1318009), feldspar, and coal in animals by nose only exposures. The cytotoxicity of the same minerals was to be determined in in-vitro tests and an evaluation was to be made regarding the data to provide comparative cytotoxic correlations on fibrogenicity and to develop information which would be useful in interpreting human exposure effects. In-vitro studies showed that bentonite, kaolin, silica, and vermiculite had the greatest hemolytic activity and talc, coal, and feldspar the least. Significant release of the cytosolic enzyme, lactate-dehydrogenase, was observed in-vitro with kaolin, silica, and vermiculite. Two lysosomal enzymes, beta-glucuronidase and beta-N- acetylglucosaminidase, were significantly released after in-vitro treatment with kaolin, silica, vermiculite, and talc. In-vivo studies showed that silica, kaolin, bentonite, vermiculite, and feldspar all induced an initial acute pulmonary response; however, there appeared to be no correlation between this acute response in-vivo and the chronic pulmonary affects of these minerals. These studies also indicated that the initial pulmonary response reflected in in-vitro studies was not correlated with the chronic response of the dust. [Description provided by NIOSH]
• Subjects:
  Dust Laboratories Lung Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  NIOSH-Author; Fibrous-bodies; Inhalation-studies; Laboratory-animals; Respiratory-system-disorders; Dust-inhalation; Mineral-dusts; Lung-function; In-vivo-study; In-vitro-study
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-32
• NIOSHTIC Number:
  nn:00197163
• Citation:
  NIOSH; :1-32
• CAS Registry Number:
  Bentonite (CAS RN 1302-78-9) ; Kaolin (CAS RN 1332-58-7) ; Silica (CAS RN 7631-86-9) ; Talc (Mg3H2(SiO3)4) (CAS RN 14807-96-6) ; Vermiculite (Mg0.33[Mg2-3(Al0-1Fe0-1)0-1](Si2.33-3.33Al0.67-1.67)(OH)2O10.4H2O) (CAS RN 1318-00-9)
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  False
• Source Full Name:
  Division of Respiratory Disease Studies, NIOSH, U.S. Department of Health and Human Services, Morgantown, West Virginia
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243019/cdc_243019_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]