Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Le, Mai Quynh ; Lam, Ha Minh ; Cuong, Vuong Duc ; Lam, Tommy Tsan-Yuk ; Halpin, Rebecca A. ; Wentworth, David E. ; Hien, Nguyen Tran ; Thanh, Le Thi ; Phuong, Hoang Vu Mai ; Horby, Peter ; Boni, Maciej F.
• Description:
  Understanding global influenza migration and persistence is crucial for vaccine strain selection. Using 240 new human influenza A virus whole genomes collected in Vietnam during 2001-2008, we looked for persistence patterns and migratory connections between Vietnam and other countries. We found that viruses in Vietnam migrate to and from China, Hong Kong, Taiwan, Cambodia, Japan, South Korea, and the United States. We attempted to reduce geographic bias by generating phylogenies subsampled at the year and country levels. However, migration events in these phylogenies were still driven by the presence or absence of sequence data, indicating that an epidemiologic study design that controls for prevalence is required for robust migration analysis. With whole-genome data, most migration events are not detectable from the phylogeny of the hemagglutinin segment alone, although general migratory relationships between Vietnam and other countries are visible in the hemagglutinin phylogeny. It is possible that virus lineages in Vietnam persisted for >1 year.
• Subjects:
  Genome, Viral Hemagglutinin Glycoproteins, Influenza Virus Humans Influenza, Human Influenza A Virus Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Molecular Sequence Data Phylogeny Phylogeography Public Health Surveillance

  More +
• Source:
  Emerg Infect Dis. 19(11):1756-1765.
• Document Type:
  Journal Article
• Funding:
  089276/B/09/7/Wellcome Trust/United Kingdom ; 093724/Wellcome Trust/United Kingdom ; 098511/Wellcome Trust/United Kingdom ; 098511/Z/12/Z/Wellcome Trust/United Kingdom ; HHSN272200900007C/PHS HHS/United States
• Place as Subject:
  Vietnam
• Volume:
  19
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:cae7473b136c34e4cfd833112ae9c22af9bed8c51d155c57dc0ba4462b9f14e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/20972/cdc_20972_DS1.pdf
• File Type:
  [PDF - 711.84 KB ]