Pulmonary siRNA Delivery for Lung Disease: Review of Recent Progress and Challenges

Details

• Personal Author:
  Ding L ; Knoell DL ; Oupický D ; Tang S ; Wyatt TA
• Description:
  Lung diseases are a leading cause of mortality worldwide and there exists urgent need for new therapies. Approval of the first siRNA treatments in humans has opened the door for further exploration of this therapeutic strategy for other disease states. Pulmonary delivery of siRNA-based biopharmaceuticals offers the potential to address multiple unmet medical needs in lung-related diseases because of the specific physiology of the lung and characteristic properties of siRNA. Inhalation-based siRNA delivery designed for efficient, targeted delivery to specific cells within the lung holds great promise. Efficient delivery of siRNA directly to the lung, however, is relatively complex. This review focuses on the barriers that impact pulmonary siRNA delivery and successful recent approaches to advance this field forward. We focus on the pulmonary barriers that affect siRNA delivery, the disease-dependent pathological changes and their role in pulmonary disease and impact on siRNA delivery, as well as the recent development on the pulmonary siRNA delivery systems. [Description provided by NIOSH]
• Subjects:
  Biopharmaceutics Drug Therapy Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Pulmonary Delivery Drug Therapy Inhalation Lung Disease Non-viral Vectors Pharmaceuticals Physiological Effects Pulmonary Barriers Pulmonary System Disorders Ribonucleic Acids RNA SiRNA Therapeutic Agents

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• ISSN:
  0168-3659
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  330
• NIOSHTIC Number:
  nn:20066045
• Citation:
  J Control Release 2021 Feb; 330:977-991
• Contact Point Address:
  David Oupický, Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA
• Email:
  david.oupicky@unmc.edu
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Journal of Controlled Release
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:78986fb8ab620c821f76a9f2477bb2d5da6234689b48dbd6a685d7dcd1468077dabbad5d607f0c024e6bcd2451a0e8372d2317c9f4262848bc4c974a66780b21
• Download URL:
  https://stacks.cdc.gov/view/cdc/209128/cdc_209128_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]