Transdermal drug delivery: a perspective.

Details

• Personal Author:
  Guy RH ; Hadgraft J
• Description:
  The use of transdermal drug delivery as a method for systemic drug administration was reviewed. Advantages of transdermal drug delivery included patient compliance, simplicity of administration, immediate reduction of plasma levels of the drug upon removal of the device, reduction in drug related side effects, maintenance of sustained controllable drug levels in the plasma, and elimination of first pass metabolism. The primary limitations of the method were the barrier properties of the skin and potential inflammatory or allergic reactions due to drug bioactivity. The four drugs approved for transdermal delivery in the United States, clonidine, estradiol, nitroglycerin, and scopolamine, and two drugs under experimental review for transdermal methodology, nicotine and timolol, were described. Discussion focused on the physicochemical properties of the drugs and percutaneous absorption modelling in relation to optimal conditions for successful transdermal delivery and problems relating to skin sensitivity, cutaneous metabolism, and tolerance. [Description provided by NIOSH]
• Subjects:
  Biopharmaceutics Dermatitis Drug Therapy Occupational Health Safety Skin Skin Absorption
• Keywords:
  Biokinetics Drug-therapy Medical-treatment NIOSH-Grant NIOSH-Publication Pharmaceuticals Pharmacodynamics Skin-absorption Therapeutic-agents
• ISSN:
  0168-3659
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  237-251
• Volume:
  4
• Issue:
  4
• NIOSHTIC Number:
  nn:00185577
• Citation:
  J Control Release 1987 Feb; 4(4):237-251
• Contact Point Address:
  Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
• Federal Fiscal Year:
  1987
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  True
• Start Date:
  19840928
• Source Full Name:
  Journal of Controlled Release
• End Date:
  19871231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e4b55863a0bd891572fc66d47a68a262799b26fdc5112e3175ab7827b632932170e965bf85cfa9d0b7b16c17624921e8be344c7bcc4824868e962a2c31fc3e3d
• Download URL:
  https://stacks.cdc.gov/view/cdc/185721/cdc_185721_DS1.pdf
• File Type:
  [PDF - 1.36 MB ]