Serum Antioxidant Status and Mortality from Influenza and Pneumonia in US Adults

Details

• Personal Author:
  Hu H ; Kang H ; Park SK
• Description:
  Objective: We examined the association between serum antioxidant status and mortality from influenza and pneumonia in US adults. Design: Serum concentrations of antioxidants included vitamin C, vitamin A, vitamin E, sum of a- and beta-carotene, beta-cryptoxanthin, lutein + zeaxanthin and lycopene. We computed total antioxidant capacity (TAC) as a measure of composite antioxidant status in serum. Survey-weighted Cox proportional hazard models were used to compute hazard ratios (HR) and 95 % CI comparing quartiles of each antioxidant and TAC. Setting: Data from the US National Health and Nutrition Examination Survey (NHANES)-III. Participants: A total of 7428 NHANES-III participants ≥45 years of age. Results: With a weighted-median follow-up of 16.8 years, 154 participants died from influenza/pneumonia. After adjustment for covariates, serum vitamin C, the sum of a- and beta-carotene and TAC were nonlinearly associated with influenza/pneumonia mortality, with the statistically significant smallest HR at the third quartile v. the first quartile (HR = 0.38 (95 % CI: 0.19, 0.77), 0.29 (0.16, 0.51) and 0.30 (0.15, 0.59), respectively). HR comparing the fourth v. the first quartiles were weaker and nonsignificant: 0.57 (95 % CI: 0.27, 1.17), 0.70 (0.41, 1.19) and 0.65 (0.31, 1.35), respectively. Serum lycopene had a monotonic association with influenza/pneumonia mortality (HR = 0.43 (95 % CI: 0.23, 0.83) comparing the fourth v. the first quartile, Pfor trend = 0.01). Conclusions: The current study suggests that antioxidant intake as reflected by serum concentrations may reduce mortality risk from influenza or pneumonia in the US general population. These findings warrant further confirmation in other populations with different settings (e.g. a shorter-term association with influenza infection). [Description provided by NIOSH]
• Subjects:
  Antioxidants Communicable Diseases Epidemiology Immune System Influenza, Human Mortality Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Micronutrients Immune System Infectious Disease Influenza Longitudinal Study Lycopene Mortality Rates Nutrition Oxidative Stress Pneumonia Reactive Oxygen Species ROS Vitamin C Vitamins

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• ISSN:
  1368-9800
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Michigan ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  12
• NIOSHTIC Number:
  nn:20066021
• Citation:
  Public Health Nutr 2022 Dec; 25(12):3466-3475
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
• Email:
  sungkyun@umich.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Public Health Nutrition
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9771a6328e77467b2fb4f6c2d7f11409c1805c4041c6b77b93aaf4d6aec4d702cca3d7b890b4c8cecfc0fb35a4be9b396ba2898381e5134e04999e951554e9fe
• Download URL:
  https://stacks.cdc.gov/view/cdc/209106/cdc_209106_DS1.pdf
• File Type:
  [PDF - 698.32 KB ]