Melatonin, Nitric Oxide Synthase and Oxidative Stress: Implications in Aging

Details

• Personal Author:
  Bondy SC ; Ge Y-W ; Lahiri DK ; Nurnberger JI Jr. ; Yang EY
• Description:
  Age-related changes in cerebral functions are believed to be partially due to an imbalance between pro-oxidant and antioxidant factors. To compensate for this imbalance, dietary supplementation with various antioxidant agents is being tested. We have been studying the neuroprotective and biochemical role of melatonin. Melatonin, an indoleamine derivative of serotonin, is synthesized within the pineal body, and melatonin levels in the plasma have been noted to decrease with age. The effects of addition of melatonin to the diet over an extended time have been studied with emphasis on age-related changes in two indices of oxidant activity: the rate of formation of reactive oxygen species (ROS) and the activity of nitric oxide synthase (NOS). Ages of mice that reflected middle adulthood and pre-senescent periods rather than stages of early development or extreme age were selected. [Description provided by NIOSH]
• Subjects:
  Aging Animals Antioxidants Biochemistry Nervous System Nitric Oxide Occupational Health Safety
• Keywords:
  Animal Studies Neurotoxicity Nitric Oxide Oxidative Stress Reactive Oxygen Species ROS
• ISBN:
  9781441933881
• Publisher:
  Springer Science+Business Media
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  California ; Indiana ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  245-248
• Volume:
  53
• NIOSHTIC Number:
  nn:20058154
• Citation:
  Catecholamine research: from molecular insights to clinical medicine. Nagatsu T, Nabeshima T, McCarty R, Goldstein DS eds. New York: Springer Science+Business Media, 2002 Oct; 53:245-248
• Contact Point Address:
  D.K. Lahiri, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive Indianapolis, IN 42602
• CAS Registry Number:
  Melatonin (CAS RN 73-31-4) ; Nitric oxide (CAS RN 10102-43-9)
• Editor(s):
  Nagatsu T; Nabeshima T; McCarty R; Goldstein DS
• Federal Fiscal Year:
  2003
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  False
• Start Date:
  19990701
• Source Full Name:
  Catecholamine research: from molecular insights to clinical medicine
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:744892ce571f54232bda6ace933f3f4bcbb699561db5d6ac8ecccb3bdcc2a45e71a253e54a22cdf4c1ac100081de34fb3f6f9203f176c4bef2476f9db66fb564
• Download URL:
  https://stacks.cdc.gov/view/cdc/221294/cdc_221294_DS1.pdf
• File Type:
  [PDF - 1.52 MB ]