R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Sleeman, Katrina; Guo, Zhu; Barnes, John; Shaw, Michael; Stevens, James; Gubareva, Larisa V.

doi:10.3201/eid1909.130724

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R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

2013
By Sleeman, Katrina ; Guo, Zhu ; Barnes, John ; ...
http://dx.doi.org/10.3201/eid1909.130724
Source: Emerg Infect Dis. 19(9):1521-1524.

[PDF-562.27 KB]

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Sleeman, Katrina ; Guo, Zhu ; Barnes, John ; Shaw, Michael ; Stevens, James ; ... More +

Sleeman, Katrina ; Guo, Zhu ; Barnes, John ; Shaw, Michael ; Stevens, James ; Gubareva, Larisa V. Less -
Description:

Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.
Subjects:

[+]

Antiviral Agents Disease Outbreaks Dispatch Drug Resistance, Viral Humans Influenza, Human Influenza A Virus, H7N9 Subtype Microbial Sensitivity Tests Neuraminidase
Source:

Emerg Infect Dis. 19(9):1521-1524.
Document Type:

Journal Article
Place as Subject:

China
Location:

Asia
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:61038a63140e52101a5141d2dc3a7e4483ee6266dc5eeaf494c412b92896635e
Download URL:

https://stacks.cdc.gov/view/cdc/20909/cdc_20909_DS1.pdf
File Type:

	13-0724.nxml	txt
	license.txt	txt

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