R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sleeman, Katrina ; Guo, Zhu ; Barnes, John ; Shaw, Michael ; Stevens, James ; Gubareva, Larisa V.
• Description:
  Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.
• Subjects:
  Antiviral Agents Disease Outbreaks Dispatch Drug Resistance, Viral Humans Influenza, Human Influenza A Virus, H7N9 Subtype Microbial Sensitivity Tests Neuraminidase
• Source:
  Emerg Infect Dis. 19(9):1521-1524.
• Document Type:
  Journal Article
• Place as Subject:
  China
• Location:
  Asia
• Volume:
  19
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:61038a63140e52101a5141d2dc3a7e4483ee6266dc5eeaf494c412b92896635e
• Download URL:
  https://stacks.cdc.gov/view/cdc/20909/cdc_20909_DS1.pdf
• File Type:
  [PDF - 562.27 KB ]