R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Sleeman, Katrina; Guo, Zhu; Barnes, John; Shaw, Michael; Stevens, James; Gubareva, Larisa V.

doi:10.3201/eid1909.130724

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R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Published Date:

2013

Publisher's site:

http://dx.doi.org/10.3201/eid1909.130724 New Site Icon

Source:

Emerg Infect Dis. 19(9):1521-1524.

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Details:

Personal Authors:

Sleeman, Katrina ; Guo, Zhu ; Barnes, John ; Shaw, Michael ; Stevens, James ; ... More ▼

Keywords:

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Description:

Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases
CDC Public Access

Supporting Files:

	13-0724.nxml	text/plain
	license.txt	text/plain

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