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R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses
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  1. Characterization of Drug-Resistant Influenza A(H7N9) Variants Isolated From an Oseltamivir-Treated Patient in Taiwan
    Personal Author:
    Marjuki, Henju; Mishin, Vasiliy P.; Chesnokov, Anton P.; Jones, Joyce; De La Cruz, Juan A.; Sleeman, Katrina; Tamura, Daisuke; Nguyen, Ha T.; Wu, Ho-Sheng; Chang, Feng-Yee; Liu, Ming-Tsan; Fry, Alicia M.; Cox, Nancy J.; Villanueva, Julie M.; Davis, Charles T.; Gubareva, Larisa V.;
    Published Date:
    August 14 2014
    Source:
    J Infect Dis. 211(2):249-257
    Description:
    Background.Patients contracting influenza A(H7N9) infection often developed severe disease causing respiratory failure. Neuraminidase (NA) inhibitors (NAIs) are the primary option for treatment, but information on drugresistance markers for influenza...
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  2. An Investigational Antiviral Drug, DAS181, Effectively Inhibits Replication of Zoonotic Influenza A Virus Subtype H7N9 and Protects Mice From Lethality
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    Marjuki, Henju; Mishin, Vasiliy P.; Chesnokov, Anton P.; De La Cruz, Juan A.; Fry, Alicia M.; Villanueva, Julie; Gubareva, Larisa V.;
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    Feb 25 2014
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    Human infections caused by avian influenza A virus type subtype H7N9 have been associated with substantial morbidity and mortality. Emergence of virus variants carrying markers of decreased susceptibility to neuraminidase inhibitors was reported. Her...
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  3. Detection of oseltamivir‐resistant zoonotic and animal influenza A viruses using the rapid influenza antiviral resistance test
    Personal Author:
    Hodges, Erin N.; Mishin, Vasiliy P.; De la Cruz, Juan; Guo, Zhu; Nguyen, Ha T.; Fallows, Eric; Stevens, James; Wentworth, David E.; Davis, Charles Todd; Gubareva, Larisa V.;
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    June 11 2019
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    Influenza Other Respir Viruses. 13(5):522-527
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    Mutations in the influenza virus neuraminidase (NA) that cause reduced susceptibility to the NA inhibitor (NAI) oseltamivir may occur naturally or following antiviral treatment. Currently, detection uses either a traditional NA inhibition assay or ge...
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  4. Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China
    Personal Author:
    Ke, Changwen; Mok, Chris Ka Pun; Zhu, Wenfei; Zhou, Haibo; He, Jianfeng; Guan, Wenda; Wu, Jie; Song, Wenjun; Wang, Dayan; Liu, Jiexiong; Lin, Qinhan; Chu, Daniel Ka Wing; Yang, Lei; Zhong, Nanshan; Yang, Zifeng; Shu, Yuelong; Peiris, Joseph Sriyal Malik;
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    Aug 15 2017
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    Emerg Infect Dis. 23(8):1332-1340.
    Description:
    The recent increase in zoonotic avian influenza A(H7N9) disease in China is a cause of public health concern. Most of the A(H7N9) viruses previously reported have been of low pathogenicity. We report the fatal case of a patient in China who was infec...
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  5. PCR for Detection of Oseltamivir Resistance Mutation in Influenza A(H7N9) Virus
    Personal Author:
    Wang, Wei; Song, Zhigang; Guan, Wencai; Liu, Yi; Zhang, Xiaonan; Xu, Lei; Li, Jianhua; Yuan, Zhenghong; Hu, Yunwen;
    Published Date:
    May 2014
    Source:
    Emerg Infect Dis. 20(5):847-849.
    Description:
    Sensitive molecular techniques are needed for rapid detection of the R292K oseltamivir-resistant mutant of influenza A(H7/N9) virus strain to monitor its transmission and guide antiviral treatment. We developed a real-time reverse transcription PCR a...
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