R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Sleeman, Katrina; Guo, Zhu; Barnes, John; Shaw, Michael; Stevens, James; Gubareva, Larisa V.

doi:10.3201/eid1909.130724

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Published Date:

2013

Publisher's site:

http://dx.doi.org/10.3201/eid1909.130724 New Site Icon

Source:

Emerg Infect Dis. 19(9):1521-1524.

[PDF-562.27 KB]

Details:

Personal Authors:

Sleeman, Katrina ; Guo, Zhu ; Barnes, John ; Shaw, Michael ; Stevens, James ; ... More ▼

Keywords:

[+]

Description:

Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases
CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	13-0724.nxml	text/plain
	license.txt	text/plain

No Related Documents.

You May Also Like:

An Investigational Antiviral Drug, DAS181, Effectively Inhibits Replication of Zoonotic Influenza A Virus Subtype H7N9 and Protects Mice From Lethality

Personal Author:

Marjuki, Henju; Mishin, Vasiliy P.; Chesnokov, Anton P.; De La Cruz, Juan A.; Fry, Alicia M.; Villanueva, Julie; Gubareva, Larisa V.;

Published:

Feb 25 2014

Source:

J Infect Dis. 2014; 210(3):435-440.

Description:

Human infections caused by avian influenza A virus type subtype H7N9 have been associated with substantial morbidity and mortality. Emergence of virus variants carrying markers of decreased susceptibility to neuraminidase inhibitors was reported. Her...

File Type:

[PDF - 816.01 KB]
Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China

Personal Author:

Ke, Changwen; Mok, Chris Ka Pun; Zhu, Wenfei; Zhou, Haibo; He, Jianfeng; Guan, Wenda; Wu, Jie; Song, Wenjun; Wang, Dayan; Liu, Jiexiong; Lin, Qinhan; Chu, Daniel Ka Wing; Yang, Lei; Zhong, Nanshan; Yang, Zifeng; Shu, Yuelong; Peiris, Joseph Sriyal Malik;

Published:

Aug 15 2017

Source:

Emerg Infect Dis. 23(8):1332-1340.

Description:

The recent increase in zoonotic avian influenza A(H7N9) disease in China is a cause of public health concern. Most of the A(H7N9) viruses previously reported have been of low pathogenicity. We report the fatal case of a patient in China who was infec...

File Type:

[PDF - 2.04 MB]
PCR for Detection of Oseltamivir Resistance Mutation in Influenza A(H7N9) Virus

Personal Author:

Wang, Wei; Song, Zhigang; Guan, Wencai; Liu, Yi; Zhang, Xiaonan; Xu, Lei; Li, Jianhua; Yuan, Zhenghong; Hu, Yunwen;

Published:

May 2014

Source:

Emerg Infect Dis. 20(5):847-849.

Description:

Sensitive molecular techniques are needed for rapid detection of the R292K oseltamivir-resistant mutant of influenza A(H7/N9) virus strain to monitor its transmission and guide antiviral treatment. We developed a real-time reverse transcription PCR a...

File Type:

[PDF - 321.28 KB]
Mutations of Novel Influenza A(H10N8) Virus in Chicken Eggs and MDCK Cells

Personal Author:

Yang, Jian; Zhang, Ting; Guo, Li; Hu, Yongfeng; Li, Jinlin; Su, Haoxiang; Xiao, Yan; Ren, Xianwen; Dong, Jie; Sun, Lilian; Xiao, Yan; Li, Li; Yang, Fan; Wang, Jianwei; Yuan, Hui; Jin, Qi;

Published:

Sep 2014

Source:

Emerg Infect Dis. 20(9):1541-1543.

Description:

The recent emergence of human infection with influenza A(H10N8) virus is an urgent public health concern. Genomic analysis showed that the virus was conserved in chicken eggs but presented substantial adaptive mutations in MDCK cells. Our results pro...

File Type:

[PDF - 393.05 KB]
Poultry farms as a source of avian influenza A (H7N9) virus reassortment and human infection

Personal Author:

Wu, Donglin; Zou, Shumei; Bai, Tian; Li, Jing; Zhao, Xiang; Yang, Lei; Liu, Hongmin; Li, Xiaodan; Yang, Xianda; Xin, Li; Xu, Shuang; Zou, Xiaohui; Li, Xiyan; Wang, Ao; Guo, Junfeng; Sun, Bingxin; Huang, Weijuan; Zhang, Ye; Li, Xiang; Gao, Rongbao; Shen, Bo; Chen, Tao; Dong, Jie; Wei, Hejiang; Wang, Shiwen; Li, Qun; Li, Dexin; Wu, Guizhen; Feng, Zijian; Gao, George F.; Wang, Yu; Wang, Dayan; Fan, Ming; Shu, Yuelong;

Published:

Jan 15 2015

Source:

Sci Rep. 2015; 5.

Description:

Live poultry markets are a source of human infection with avian influenza A (H7N9) virus. On February 21, 2014, a poultry farmer infected with H7N9 virus was identified in Jilin, China, and H7N9 and H9N2 viruses were isolated from the patient's farm....

File Type:

[PDF - 2.21 MB]