Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1909.130724
Personal Author:
Sleeman, Katrina; Guo, Zhu; Barnes, John; Shaw, Michael; Stevens, James; ... More +
Sleeman, Katrina; Guo, Zhu; Barnes, John; Shaw, Michael; Stevens, James; Gubareva, Larisa V.; Less -
Description:
Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.
Subject:
[+]
Antiviral Agents
Disease Outbreaks
Dispatch
Drug Resistance, Viral
Humans
Influenza, Human
Influenza A Virus, H7N9 Subtype
Microbial Sensitivity Tests
Neuraminidase

Source:
Emerg Infect Dis. 19(9):1521-1524.;
Document Type:
Journal Article;
Place as Subject:
China;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:61038a63140e52101a5141d2dc3a7e4483ee6266dc5eeaf494c412b92896635e
File Type:

Supporting Files

• 	13-0724.nxml	txt
  	license.txt	txt

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