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R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses
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2013
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Source: Emerg Infect Dis. 19(9):1521-1524.
[PDF-562.27 KB]
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Alternative Title:Emerg Infect Dis
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Description:Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.
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Volume:19
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Issue:9
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