Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals from a North American Gaming Venue: December 2020–August 2021

Details

• Personal Author:
  Campillo Luna J ; Cantley L ; Hager K ; Liu J ; Redlich CA ; Smith RF ; Wisnewski AV
• Description:
  Objective: This study aims to evaluate COVID-19 cases and vaccine responses among workers in the gaming/entertainment industry. Methods: Participants provided detailed information on occupational risk factors, demographics, COVID-19 history, and vaccination status through questionnaire. Enzyme-linked immunosorbent assays were used to measure serum antiviral antibodies and neutralizing capacity. Results: Five hundred-fifty individuals participated with n = 228 (41.5%) returning for follow-up. At least 71% of participants were fully vaccinated within 8 months of vaccine availability and COVID-19 rates declined concomitantly. Serum anti-spike IgG levels and neutralizing capacity were significantly (P < 0.001) associated COVID-19 history and vaccine type, but not occupational risk factors, and declined (on average 36%) within 5 months. Few vaccine nonresponders (n = 12) and "breakthrough" infections (n = 1) were noted. Conclusions: COVID-19 vaccination was associated with a marked decrease in infections; however, individual humoral responses varied and declined significantly over time. [Description provided by NIOSH]
• Subjects:
  Antibodies Communicable Diseases Demography Men Occupational Health Risk Assessment Risk Factors Safety Surveys And Questionnaires Women Workplace

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• Keywords:
  ACE2r Adenovirus Antibody Antigen Author Keywords: COVID-19 Breakthrough Casino COVID-19 Demographic Characteristics Employee Entertainment Entertainment Industry Environmental Ethnicity Exposure Face Gambling Gaming Humans IgG Immunize Infection Job Johnson And Johnson Mask Medicine Moderna MRNA Neutralization Nonresponder Occupational Pfizer-BioNTech Questionnaires Race RBD Receptor Binding Domain Risk Factors SARS-CoV-2 Serum Spike Statistical Analysis Surrogate Vaccine Vaccines Virus Work Environment Worker Workers

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  64
• Issue:
  9
• NIOSHTIC Number:
  nn:20065972
• Citation:
  J Occup Environ Med 2022 Sep; 64(9):788-796
• Contact Point Address:
  Adam V. Wisnewski, PhD, Department Internal Medicine, Yale University School of Medicine, 1 Gilbert St, TAC-S420, New Haven, CT 06519
• Email:
  adam.wisnewski@yale.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  Yale University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:11f19058c9ec2dd2aeabab3c58c14051ab6a4cd79e2deda88a04e08a27ebd38a50830a8e61a2d1e6eff65760b49503dbe0ab5768a825f748a21fcdc2283d02aa
• Download URL:
  https://stacks.cdc.gov/view/cdc/209065/cdc_209065_DS1.pdf
• File Type:
  [PDF - 398.65 KB ]