Concentration-Response Relationships Between Hourly Particulate Matter and Ischemic Events: A Case-Crossover Analysis of Effect Modification by Season and Air-Mass Origin

Details

• Personal Author:
  Adar SD ; Dayan U ; Golovner M ; Levy I ; Nirel R ; Peretz A ; Vakulenko-Lagun B
• Description:
  Most studies linking cardiovascular disease with particulate matter (PM) exposures have focused on total mass concentrations, regardless of their origin. However, the origin of an air mass is inherently linked to particle composition and possible toxicity. We examine how the concentration-response relation between hourly PM exposure and ischemic events is modified by air-mass origin and season. Using telemedicine data, we conducted a case-crossover study of 1855 confirmed ischemic cardiac events in Israel (2005-2013). Based on measurements at three fixed-sites in Tel Aviv and Haifa, ambient PM with diameter < 2.5 µm (PM2.5) and 2.5-10 µm (PM10-2.5) concentrations during the hours before event onset were compared with matched control periods using conditional logistic regression that allowed for non-linearity. We also examined effect modification of these associations based on the geographical origin of each air mass by season. Independent of the geographical origin of the air mass, we observed concentration-response curves that were supralinear. For example, the overall odds ratios (ORs) of ischemic events for an increase of 10-µg/m3 in the 2-h average of PM10-2.5 were 1.08 (95% confidence interval (CI): 1.03-1.14) and 1.00 (0.99-1.01) at the median (17.8 µg/m3) and 95th percentile (82.3 µg/m3) values, respectively. Associations were strongest at low levels of PM10-2.5 when air comes from central Europe in the summer (OR: 1.27; 95% CI: 1.06, 1.52). Our study demonstrates that hourly associations between PM2.5 and PM10-2.5 and ischemic cardiac events are supralinear during diverse pollution conditions in a single population that experiences a wide range of exposure levels. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Epidemiology Occupational Health Particulate Matter Safety
• Keywords:
  Air Mass Back-trajectory Air Pollution Author Keywords: Coarse Particulate Matter Cardiovascular Disease Environmental Health Exposure-response Curve Particulates Seasonal Factors Short-term Exposure Telemedicine
• ISSN:
  0048-9697
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  760
• NIOSHTIC Number:
  nn:20070586
• Citation:
  Sci Total Environ 2021 Mar; 760:143407
• Contact Point Address:
  Ronit Nirel, Department of Statistics and Data Science, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 9190501, Israel
• Email:
  nirelr@mail.huji.ac.il
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Science of the Total Environment
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8413efb24d86c93713a1e82a2a0b09906161848bd428402f9654d62ecc45a3dc7cfb9d6f13999035cfc92c9b99045ce8d7a68810dc853c288d076226f3331824
• Download URL:
  https://stacks.cdc.gov/view/cdc/208766/cdc_208766_DS1.pdf
• File Type:
  [PDF - 1.04 MB ]