Mouse Pulmonary Response Following Solid Surface Composite Dust Inhalation (Dataset)

Details

• Personal Author:
  Battelli LA ; Friend SA ; Jackson M ; Keeley SL ; Knepp AK ; Mandler WK ; McKinney WG ; Qian Y
• Description:
  Solid surface composites (SSCs) are a widely used construction material that can generate dust and volatile organic chemicals (VOCs) during fabrication. Exposure to SSC dust has been linked to pulmonary health effects, including pulmonary fibrosis and lung inflammation. Previous studies have investigated the toxicity of SSC particles using in vitro and in vivo models, but these studies have limitations. For example, they often relied on pre-generated particles that may not accurately represent the size distribution and characteristics of aerosols encountered in real-world settings. Additionally, these models did not capture the co-exposure to VOCs that can occur during SSC fabrication. To address these limitations, we developed a novel apparatus capable of real-time generation of SSC sawing particles and their simultaneous delivery to rodents via whole-body inhalation. This approach allows for a more accurate assessment of SSC toxicity under conditions that better reflect workplace exposure scenarios. The present study utilizes this system to characterize the acute pulmonary response in mice following a 4-day inhalation exposure to real-time generated SSC aerosols, with evaluations at 1, 6, 27, and 56 days post-exposure. [Description provided by NIOSH]
• Subjects:
  Construction Industry Construction Materials Dust Lung Occupational Health Particulate Matter Respiratory System Safety Toxicology Volatile Organic Compounds
• Keywords:
  Construction Materials Dust Particles Dusts Inhalation Studies Pulmonary Effects VOCs Volatile Organic Compounds
• DOI:
  https://doi.org/10.26616/NIOSHRD-1112-2025-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  Philadelphia Region [OSHA] ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20070536
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1112-2025-0, 2025 Apr; :dataset
• Contact Point Address:
  Pathology and Physiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 USA
• Federal Fiscal Year:
  2025
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Mouse pulmonary response following solid surface composite dust inhalation
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1b933054c7abd33aab9634419f1ecaf176d7d85f1dac555b58fd01d4e53ef9863bcc7d2c427aed14255f3d1d249e940d8257785934db2d5698d37e7e01931c83
• Download URL:
  https://stacks.cdc.gov/view/cdc/208721/cdc_208721_DS1.pdf
• File Type:
  [PDF - 257.86 KB ]