A Preliminary Quantitative Risk Assessment for Inhalation Exposure to Glutaraldehyde

Details

• Personal Author:
  Dankovic, David A. ; Pandalai, Sudah P.
• Description:
  Glutaraldehyde (Chemical Abstracts Service [CAS] registry number 111-30-8) has various occupational uses and is associated with adverse health effects including respiratory tract irritation, asthma, and chronic obstructive pulmonary disease. A quantitative risk assessment was conducted to evaluate the likelihood of adverse health effects associated with differing levels of occupational inhalation exposure to glutaraldehyde. Dose-response models were fit to data from a 2-year glutaraldehyde inhalation exposure bioassay conducted by the National Toxicology Program. The benchmark concentration lower bound values of 32 and 44 parts per billion (ppb) were based on bioassay data for female rats and mice that developed squamous epithelium inflammation and respiratory epithelium squamous metaplasia, respectively. These values were used as a point of departure to determine exposure levels relevant to the occupational setting. Extrapolation from rodents to humans assumed a 40-h workweek and an 8-fold uncertainty factor to account for interspecies and interindividual variability. Adjusted benchmark lower bound concentrations of 3 and 4.1 ppb were calculated for inhalation exposure to glutaraldehyde using the endpoints observed in rat and mouse models. Due to the extrapolation parameters used in deriving this result, these findings have applicability for exposure to glutaraldehyde in the occupational setting. [Description provided by NIOSH]
• Subjects:
  Occupational Exposure Occupational Health Respiratory System Risk Assessment Safety
• Keywords:
  Author Keywords: Chemical Risk Assessment Dose-response Modeling Dose Response Glutaraldehyde Inhalation Studies Model Average Model Averaging Occupational Exposure Quantitative Risk Assessment Respiratory Irritants
• ISSN:
  0260-437X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Chicago Region [OSHA] ; Ohio
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20070534
• Citation:
  J Appl Toxicol 2025 Feb; :[Epub ahead of print]
• Contact Point Address:
  Sudha P. Pandalai, Division of Science Integration, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA
• Email:
  spandalai@cdc.gov
• CAS Registry Number:
  Glutaraldehyde (CAS RN 111-30-8)
• Federal Fiscal Year:
  2025
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Applied Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f83b63546b95ddbdccc16ebadb358f80ddf833e9fbc3279c7182d7c04c7d198c27d232624611ecfbead78ded7af3d797f1e299c9b3849f9156b3320c443c8b8f
• Download URL:
  https://stacks.cdc.gov/view/cdc/208720/cdc_208720_DS1.pdf
• File Type:
  [PDF - 502.47 KB ]