The ETS Domain-Containing Hematopoietic Transcription Factor PU.1 Mediates the Induction of Arachidonate 5-Lipoxygenase by Multi-Walled Carbon Nanotubes in Macrophages In Vitro (Dataset)

Details

• Personal Author:
  Gu JK ; Lim CS ; Ma Q
• Description:
  Fibrogenic multi-walled carbon nanotubes (MWCNTs) polarize macrophages to M1 cells with elevated production of proinflammatory lipid mediators (LMs) to boost acute inflammation. Here we examined the mechanism by which MWCNTs (Mitsui-7) induce arachidonate 5-lypoxygenase (Alox5) critical for production of chemotactic LM leukotriene B4 (LTB4) in murine and human macrophages. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Environmental Health Environmental Pollution Mining Occupational Exposure Occupational Health Safety
• Keywords:
  Hematopoietic System Macrophages Multi-walled Carbon Nanotubes MWCNT Nanotoxicology
• DOI:
  https://doi.org/10.26616/NIOSHRD-1109-2025-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  Philadelphia Region [OSHA] ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20070508
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1109-2025-0, 2025 Feb; :dataset
• Contact Point Address:
  Physical Effects Research Branch (PERB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505
• Federal Fiscal Year:
  2025
• NORA Priority Area:
  Construction ; Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The ETS domain-containing hematopoietic transcription factor PU.1 mediates the induction of arachidonate 5-lipoxygenase by multi-walled carbon nanotubes in macrophages in vitro
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:be52147c4556e68e0e728add52f7a19b4ecbc2e8f09a70e8d7ecb19960c5f67af570d1f18407ab2777ec228ab9bcb281cde5f546005129720b4985486b3a83bf
• Download URL:
  https://stacks.cdc.gov/view/cdc/208706/cdc_208706_DS1.pdf
• File Type:
  [PDF - 139.15 KB ]