The ETS Domain-Containing Hematopoietic Transcription Factor PU.1 Mediates the Induction of Arachidonate 5-Lipoxygenase by Multi-Walled Carbon Nanotubes in Macrophages In Vitro (Dataset)

Details

• Personal Author:
  Gu JK ; Lim CS ; Ma Q
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Download the Dataset decsribed here from Data.cdc.gov at https://doi.org/10.26616/NIOSHRD-1109-2025-0.
  
  Fibrogenic multi-walled carbon nanotubes (MWCNTs) polarize macrophages to M1 cells with elevated production of proinflammatory lipid mediators (LMs) to boost acute inflammation. Here we examined the mechanism by which MWCNTs (Mitsui-7) induce arachidonate 5-lypoxygenase (Alox5) critical for production of chemotactic LM leukotriene B4 (LTB4) in murine and human macrophages. [Description provided by NIOSH]
  
  
• Subjects:
  Environmental Exposure Environmental Health Environmental Pollution Mining Occupational Exposure Occupational Health Safety
• Keywords:
  Hematopoietic System Macrophages Multi-walled Carbon Nanotubes MWCNT Nanotoxicology
• Series:
  NIOSH Data
• DOI:
  https://doi.org/10.26616/NIOSHRD-1109-2025-0
• Landing Page:
  https://stacks.cdc.gov/view/cdc/208706
• Dataset Download URL:
  https://data.cdc.gov/download/3ix4-m2h6/application%2Fx-zip-compressed
• Identifier:
  https://doi.org/10.26616/NIOSHRD-1109-2025-0
• Format:
  ZIP folder
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  Philadelphia Region [OSHA] ; West Virginia
• Media Type:
  application/zip
• Described By Type:
  HTML Repository Page
• License:
  https://creativecommons.org/public-domain/
• Rights:
  Public Domain
• Described By:
  https://stacks.cdc.gov/view/cdc/208706
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Contact Point:
  Health Effects Laboratory Division (HELD). Toxicology and Molecular Biology Branch (TMBB)
• Pages in Document:
  1 ZIP folder
• NIOSHTIC Number:
  nn:20070508
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1109-2025-0, 2025 Feb; :dataset
• Email:
  sa-cin-webteam@cdc.gov
• Federal Fiscal Year:
  2025
• NORA Priority Area:
  Construction ; Manufacturing
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:be52147c4556e68e0e728add52f7a19b4ecbc2e8f09a70e8d7ecb19960c5f67af570d1f18407ab2777ec228ab9bcb281cde5f546005129720b4985486b3a83bf
• Download URL:
  https://stacks.cdc.gov/view/cdc/208706/cdc_208706_DS1.pdf
• File Type:
  [PDF - 139.15 KB ]