Systemic and Immunotoxicity Induced by Topical Application of Perfluoroheptane Sulfonic Acid (PFHpS) or Perfluorooctane Sulfonic Acid (PFOS) in a Murine Model (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic man-made surfactants of over 12,000 compounds that are incorporated into numerous products for their chemical and physical properties. Numerous PFAS have been associated with adverse health effects. Although there is a high potential for dermal exposure, these studies are lacking. The present study evaluated the systemic and immunotoxicity of sub-chronic 28- or 10-day dermal exposure, respectively, to of PFHpS (0.3125-2.5% or 7.82-62.5 mg/kg/dose) or PFOS (0.5% or 12.5 mg/kg/dose) in a murine model. [Description provided by NIOSH]
• Subjects:
  Immune System Laboratories Liver Occupational Health Safety Skin Surface-Active Agents
• Keywords:
  Dermal Exposures Hepatotoxicity Immune Reaction Laboratory Animals Liver Damage Per- And Polyfluoroalkyl Substances PFAS Surfactants
• DOI:
  https://doi.org/10.26616/NIOSHRD-1093-2024-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  Philadelphia Region [OSHA] ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20070204
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1093-2024-0, 2024 Oct; :dataset
• Contact Point Address:
  Allergy and Clinical Immunology Branch (ACIB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV
• CAS Registry Number:
  Perfluoroheptanesulfonic acid (CAS RN 375-92-8) ; Perfluorooctanesulfonic acid (CAS RN 1763-23-1)
• Federal Fiscal Year:
  2025
• NORA Priority Area:
  Healthcare and Social Assistance ; Oil and Gas Extraction
• Peer Reviewed:
  False
• Source Full Name:
  Systemic and immunotoxicity induced by topical application of perfluoroheptane sulfonic acid (PFHpS) or perfluorooctane sulfonic acid (PFOS) in a murine model
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dede407e66e63fd1c53ecc51323793b744b0b5c4c38702359353a5b7e2e6d17484ecbec9b216f4182995b5d07ae6ac1cdebc872928328191f29319feb5b28baf
• Download URL:
  https://stacks.cdc.gov/view/cdc/208460/cdc_208460_DS1.pdf
• File Type:
  [PDF - 100.55 KB ]