Systematic Review of Mechanistic Evidence for TiO2 Nanoparticle-Induced Lung Carcinogenicity

Details

• Personal Author:
  Bing HL ; Camassa LMA ; Mohr B ; Pathak D ; Samulin Erdem J ; Sriram K ; Wolf S ; Zienolddiny-Narui S
• Description:
  Nano-sized titanium dioxide particles (TiO2 NPs) are a high-production volume nanomaterial widely used in the paints, cosmetics, food and photovoltaics industry. However, the potential carcinogenic effects of TiO2 NPs in the lung are still unclear despite the vast number of in vitro and in vivo studies investigating TiO2 NPs. Here, we systematically reviewed the existing in vitro and in vivo mechanistic evidence of TiO2 NP lung carcinogenicity using the ten key characteristics of carcinogens for identifying and classifying carcinogens. A total of 346 studies qualified for the quality and reliability assessment, of which 206 were considered good quality. Using a weight-of-evidence approach, these studies provided mainly moderate to high confidence for the biological endpoints regarding genotoxicity, oxidative stress and chronic inflammation. A limited number of studies investigated other endpoints important to carcinogenesis, relating to proliferation and transformation, epigenetic alterations and receptor-mediated effects. In summary, TiO2 NPs might possess the ability to induce chronic inflammation and oxidative stress, but it was challenging to compare the findings in the studies due to the wide variety of TiO2 NPs differing in their physicochemical characteristics, formulation, exposure scenarios/test systems, and experimental protocols. Given the limited number of high-quality and high-reliability studies identified within this review, there is a lack of good enough mechanistic evidence for TiO2 NP lung carcinogenicity. Future toxicology/carcinogenicity research must consider including positive controls, endotoxin testing (where necessary), statistical power analysis, and relevant biological endpoints, to improve the study quality and provide reliable data for evaluating TiO2 NP-induced lung carcinogenicity. [Description provided by NIOSH]
• Subjects:
  Carcinogens Occupational Health Respiratory System Safety Titanium
• Keywords:
  Author Keywords: Titanium Dioxide Nanoparticles Carcinogenicity Inhalation Key Characteristics Of Carcinogens Lung Cancer Mechanistic Evidence Nanoparticles Oxidative Stress Quality Assessment Systematic Reviews Titanium Dioxide Weight-of-evidence Approach

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• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  437-463
• Volume:
  18
• Issue:
  5
• NIOSHTIC Number:
  nn:20070010
• Citation:
  Nanotoxicology 2024 Jul; 18(5):437-463
• Email:
  Johanna.Samulin-Erdem@stami.no
• CAS Registry Number:
  Titania (CAS RN 13463-67-7)
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:842a6a533bb8fd28c8fba901c77e2edc890fcbe525b56cd2aac76aa3311958213fa5a334d3dc8338eb6e10b844f4a74d6d8134ed7f17fe0462c742db2991f9fe
• Download URL:
  https://stacks.cdc.gov/view/cdc/208319/cdc_208319_DS1.pdf
• File Type:
  [PDF - 5.51 MB ]