Systemic and Immunotoxicity Induced by Topical Application of Perfluoroheptane Sulfonic Acid (PFHpS) or Perfluorooctane Sulfonic Acid (PFOS) in a Murine Model

Details

• Personal Author:
  Anderson, Stacey E. ; Baur R ; Cooper MP ; Jackson LG ; Lukomska E ; Shane HL ; Weatherly LM
• Description:
  Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic surfactants of over 12,000 compounds that are incorporated into numerous products for their chemical and physical properties. Studies have associated PFAS with adverse health effects. Although there is a high potential for dermal exposure, these studies are lacking. The present study evaluated the systemic and immunotoxicity of subchronic 28- or 10-days of dermal exposure, respectively, to PFHpS (0.3125-2.5% or 7.82-62.5 mg/kg/dose) or PFOS (0.5% or 12.5 mg/kg/dose) in a murine model. Elevated levels of PFHpS were detected in the serum and urine, suggesting that absorption is occurring through the dermal route. PFHpS induced significantly increased relative liver weight, significantly decreased relative spleen and thymus weight, altered serum chemistries, and altered histopathology. Additionally, PFHpS significantly reduced the humoral immune response and altered immune subsets in the spleen, suggesting immunosuppression. Gene expression changes were observed in the liver, skin, and spleen of genes involved in fatty acid metabolism, necrosis, and inflammation. Immune-cell phenotyping identified significant decreases in B-cells and CD11b+ monocyte and/or macrophages in the spleen along with decreases in eosinophils and dendritic cells in the skin. These findings support PFHpS absorption through the skin leading to liver damage and immune suppression. [Description provided by NIOSH]
• Subjects:
  Immune System Laboratories Liver Occupational Health Safety Skin Surface-Active Agents
• Keywords:
  Author Keywords: Perfluoroheptane Sulfonic Acid Dermal Dermal Exposures Hepatotoxicity Immune Immune Reaction Immunosuppression Laboratory Animals Liver Damage Per- And Polyfluoroalkyl Substances PFAS PFHpS PPAR Surfactants Toxicity

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• ISSN:
  1547-691X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  21
• Issue:
  1
• NIOSHTIC Number:
  nn:20069938
• Citation:
  J Immunotoxicol 2024 Jul; 21(1):2371868
• Contact Point Address:
  Lisa M. Weatherly, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Drive, Morgantown, WV, 26505, USA
• Email:
  nux6@cdc.gov
• CAS Registry Number:
  Perfluoroheptanesulfonic acid (CAS RN 375-92-8) ; Perfluorooctanesulfonic acid (CAS RN 1763-23-1)
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Manufacturing ; Public Safety
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Immunotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:77447d1208ebfa60961c00fe62bc2bd7136b4a3e862f837d9c8b56f04451493e1b2796607e630050aff0e1e08d34a8c23bbc3cefc1b8aaa01c0be69c9f2b732b
• Download URL:
  https://stacks.cdc.gov/view/cdc/208257/cdc_208257_DS1.pdf
• File Type:
  [PDF - 4.63 MB ]