Systemic and Immunotoxicity Induced by Topical Application of Perfluorohexane Sulfonic Acid (PFHxS) in a Murine Model (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Per- and polyfluoroalkyl substances (PFAS) are a large group of stable man-made surfactants that are incorporated into numerous products for their water and oil resistance and have been associated with adverse health effects. The present study evaluated the systemic and immunotoxicity of sub-chronic 28- or 10-day dermal exposure of PFHxS (0.625-5% or 15.63-125 mg/kg/dose) in a murine model. Elevated levels of PFHxS were detected in the serum and urine, suggesting that absorption is occurring through the dermal route. Liver weight (% body) significantly increased and spleen weight (% body) significantly deceased with PFHxS exposure supported by histopathological changes. Additionally, PFHxS significantly reduced the humoral immune response and altered immune subsets in the spleen, suggesting immunosuppression. Gene expression changes were observed in the liver, skin, and spleen with genes involved in fatty acid metabolism, necrosis, and inflammation. Immune-cell phenotyping identified significant decreases in B-cells, NK cells, and CD11b+ cells in the spleen along with increases in CD4+ and CD8+ T-cells, NK cells, and neutrophils in the skin. These findings support dermal PFHxS-induced liver damage and immune suppression. These data support PFHxS absorption through the skin and demonstrate immunotoxicity via this exposure route, raising concern about prompting the need for further investigation. [Description provided by NIOSH]
• Subjects:
  Immune System Laboratories Occupational Health Safety Skin Toxicology
• Keywords:
  Dermal Exposures Gene Expression Histopathology Immune Reaction Laboratory Animals Liver Damage Per- And Polyfluoroalkyl Substances PFAS
• DOI:
  https://doi.org/10.26616/NIOSHRD-1089-2024-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20069935
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1089-2024-0, 2024 Aug; :dataset
• Contact Point Address:
  Allergy and Clinical Immunology Branch (ACIB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV. Tel: 304.285.6024
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  False
• Source Full Name:
  Systemic and immunotoxicity induced by topical application of perfluorohexane sulfonic acid (PFHxS) in a murine model
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:71895b8f0259499c697ace8e2c6ddbb056efc5a5fd0b7ddd4f7e34dfaff09c68ebf5dfffdcd58f92f7a217eab0be923c9c09ac4886b9626b619ff30806a3b52a
• Download URL:
  https://stacks.cdc.gov/view/cdc/208256/cdc_208256_DS1.pdf
• File Type:
  [PDF - 101.31 KB ]