Potent Lung Tumor Promotion by Inhaled MWCNT (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  In the lung, carcinogenesis is a multi-stage process that includes initiation by a genotoxic agent, promotion that expands the population of cells with damaged DNA to form a tumor, and progression from benign to malignant neoplasms. We have previously shown that Mitsui-7, a long and rigid multi-walled carbon nanotube (MWCNT), promotes pulmonary carcinogenesis in a mouse model. To investigate the potential exposure threshold and dose-response for tumor promotion by this MWCNT, 3-methylcholanthrene (MC) initiated (10 µg/g, i.p., once) or vehicle (corn oil) treated B6C3F1 mice were exposed by inhalation to filtered air or MWCNT (5 mg/m3) for 5 hours/day for 0, 2, 5, or 10 days and were followed for 17 months post-exposure for evidence of lung tumors. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal Studies Carcinogenesis Dose Response Inhalation Lung Cancer Multi-walled Carbon Nanotubes MWCNT Tumorigenesis
• DOI:
  https://doi.org/10.26616/NIOSHRD-1086-2024-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20069687
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1086-2024-0, 2024 May; :dataset
• Contact Point Address:
  National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, 1000 Frederick Lane, Morgantown, WV 26508
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Potent lung tumor promotion by inhaled MWCNT
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c1e4131c4f183a626c24fc19edbcb134bc9558e87dcff256b1714883d9b4cad3438f1a5d2e7ecaea0a02a9341c4987dfe13002652bb7f5059b1512fc5823eca2
• Download URL:
  https://stacks.cdc.gov/view/cdc/208064/cdc_208064_DS1.pdf
• File Type:
  [PDF - 67.83 KB ]