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Antibiotic Perturbations to the Gut Microbiome



Details

  • Personal Author:
  • Description:
    Antibiotic-mediated perturbation of the gut microbiome is associated with numerous infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome is a complex ecological network of microorganisms, the effects of antibiotics can be highly variable. With the advent of multi-omic approaches for systems-level profiling of microbial communities, we are beginning to identify microbiome-intrinsic and microbiome-extrinsic factors that affect microbiome dynamics during antibiotic exposure and subsequent recovery. In this Review, we discuss factors that influence restructuring of the gut microbiome on antibiotic exposure. We present an overview of the currently complex picture of treatment-induced changes to the microbial community and highlight essential considerations for future investigations of antibiotic-specific outcomes. Finally, we provide a synopsis of available strategies to minimize antibiotic-induced damage or to restore the pretreatment architectures of the gut microbial community. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1740-1526
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    21
  • Issue:
    12
  • NIOSHTIC Number:
    nn:20069680
  • Citation:
    Nat Rev Microbiol 2023 Dec; 21(12):772-788
  • Contact Point Address:
    Gautam Dantas, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA
  • Email:
    dantas@wustl.edu
  • Federal Fiscal Year:
    2024
  • Performing Organization:
    Washington University, Saint Louis
  • Peer Reviewed:
    True
  • Start Date:
    20180901
  • Source Full Name:
    Nature Reviews Microbiology
  • End Date:
    20220831
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:f47d52578a24a55405ad955fabcea306f6e528c6e529db3adfb61d7f5a74c4a34ff4af106c53e07a0287392f9d72cff57c892a7ea84c3f782e0ffe0e3d536959
  • Download URL:
  • File Type:
    Filetype[PDF - 3.63 MB ]
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