High prevalence of Panton-Valentine leukocidin among methicillin-sensitive Staphylococcus aureus colonization isolates in rural Iowa

Details

• Personal Author:
  Forshey BM ; Smith TC ; Wardyn SE
• Description:
  Recent studies have shown that livestock can carry Staphylococcus aureus and transmit it to human caretakers. We conducted a pilot study to determine the prevalence and molecular epidemiology of S. aureus among rural Iowans, including individuals with livestock contact. Nasal and throat swabs were collected and plated onto selective media to isolate methicillin-susceptible and methicillin-resistant S. aureus (MRSA), followed by antibiotic resistance testing and molecular analysis of the isolates. While no MRSA was detected, overall, 23.7% (31/131) of participants were found to harbor S. aureus in their nose, throat, or both. Fifteen isolates displayed resistance to one or more tested antibiotics, and the Panton-Valentine leukocidin (PVL) genes were present at a high level (29% [9/31] of S. aureus-positive participants). Younger age and tobacco use were associated with increased risk of S. aureus carriage. Our results suggest that carriage of PVL-positive S. aureus is common among rural Iowans, even in the absence of detectable MRSA colonization. [Description provided by NIOSH]
• Subjects:
  Animals Anti-Bacterial Agents Epidemiology Genetics Livestock Microbiology Occupational Health Safety
• Keywords:
  Antibiotics Bacteria Microorganisms Molecular-biology Pharmacology
• ISSN:
  1076-6294
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  427-433
• Volume:
  18
• Issue:
  4
• NIOSHTIC Number:
  nn:20042610
• Citation:
  Microb Drug Resist 2012 Aug; 18(4):427-433
• Contact Point Address:
  Tara C. Smith, Ph.D., Department of Epidemiology, College of Public Health, University of Iowa, 105 River St., S43, Iowa City, IA 52242
• Email:
  tara-smith@uiowa.edu
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Iowa, Iowa City
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Microbial Drug Resistance: mechanism, epidemiology, and disease
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1c26a673e7d7174b96034e1701be1e6f1a9d015d3ecee6dc8274122570aacca672b2a00554ed5ae55d58d448db08e27c29f5f5a2901bbdf87f4108a29fb2cd30
• Download URL:
  https://stacks.cdc.gov/view/cdc/194780/cdc_194780_DS1.pdf
• File Type:
  [PDF - 183.51 KB ]