Firefighting, per- and Polyfluoroalkyl Substances, and DNA Methylation of Genes Associated with Prostate Cancer Risk

Details

• Personal Author:
  Beitel SC ; Burgess JL ; Caban-Martinez, Alberto J. ; Calkins MM ; Gabriel J ; Goodrich JM ; Graber JM ; Grant C ; Gulotta JJ ; Hughes J ; Littau S ; Petroff RL ; Quaid M ; Urwin D ; Wallentine D
• Description:
  Prostate cancer is the leading incident cancer among men in the United States. Firefighters are diagnosed with this disease at a rate 1.21 times higher than the average population. This increased risk may result from occupational exposures to many toxicants, including per- and polyfluoroalkyl substances (PFAS). This study assessed the association between firefighting as an occupation in general or PFAS serum levels, with DNA methylation. Only genomic regions previously linked to prostate cancer risk were selected for analysis: GSTP1, Alu repetitive elements, and the 8q24 chromosomal region. There were 444 male firefighters included in this study, with some analyses being conducted on fewer participants due to missingness. Statistical models were used to test associations between exposures and DNA methylation at CpG sites in the selected genomic regions. Exposure variables included proxies of cumulative firefighting exposures (incumbent versus academy status and years of firefighting experience) and biomarkers of PFAS exposures (serum concentrations of 9 PFAS). Proxies of cumulative exposures were associated with DNA methylation at 15 CpG sites and one region located within FAM83A (q-value <0.1). SbPFOA was associated with 19 CpG sites (q < 0.1), but due to low detection rates, this PFAS was modeled as detected versus not detected in serum. Overall, there is evidence that firefighting experience is associated with differential DNA methylation in prostate cancer risk loci, but this study did not find evidence that these differences are due to PFAS exposures specifically. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Firefighters Genetics Mutagens Occupational Health Safety
• Keywords:
  Author Keywords: DNA Methylation DNA Damage Environmental Exposure Environmental Exposures Epigenetics Fire Fighters Firefighting Genes Genetic Factors Mutagenesis Occupational Health Per- And Polyfluoroalkyl Substances PFAS Prostate Cancer

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• ISSN:
  0893-6692
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; California ; Florida ; Massachusetts ; Michigan ; New Jersey ; Ohio ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  55-66
• Volume:
  65
• Issue:
  1
• NIOSHTIC Number:
  nn:20069450
• Citation:
  Environ Mol Mutagen 2024 Jan-Feb; 65(1-2):55-66
• Contact Point Address:
  Jaclyn M. Goodrich, Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
• Email:
  gaydojac@umich.edu
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Public Safety
• Peer Reviewed:
  True
• Source Full Name:
  Environmental and Molecular Mutagenesis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ca1958c2c3394cfd00ad312f71c07893a9e63ab3248c449d5dcf67e175fe977cfe85ec113989e23fa3a820afa3f58b109701ddf75e0e11db63776e66c4202029
• Download URL:
  https://stacks.cdc.gov/view/cdc/207900/cdc_207900_DS1.pdf
• File Type:
  [PDF - 1.73 MB ]