Per- and Polyfluoroalkyl Substances, Epigenetic Age and DNA Methylation: A Cross-Sectional Study of Firefighters

Details

• Personal Author:
  Beitel S ; Burgess JL ; Caban-Martinez, Alberto J. ; Calafat, Antonia M. ; Calkins MM ; Cook Botelho J ; Dewald A ; Goodrich JM ; Graber JM ; Grant C ; Gulotta J ; Hughes J ; Jenkins T ; Jung AM ; Littau S ; Nematollahi A ; Popp C ; Slitt AL ; Stueckle, Todd A. ; Wallentine D
• Description:
  Background: Per- and polyfluoroalkyl substances (PFASs) are persistent chemicals that firefighters encounter. Epigenetic modifications, including DNA methylation, could serve as PFASs toxicity biomarkers. Methods: With a sample size of 197 firefighters, we quantified the serum concentrations of nine PFASs, blood leukocyte DNA methylation and epigenetic age indicators via the EPIC array. We examined the associations between PFASs with epigenetic age, site- and region-specific DNA methylation, adjusting for confounders. Results: Perfluorohexane sulfonate, perfluorooctanoate (PFOA) and the sum of branched isomers of perfluorooctane sulfonate (Sm-PFOS) were associated with accelerated epigenetic age. Branched PFOA, linear PFOS, perfluorononanoate, perfluorodecanoate and perfluoroundecanoate were associated with differentially methylated loci and regions. Conclusion: PFASs concentrations are associated with accelerated epigenetic age and locus-specific DNA methylation. The implications for PFASs toxicity merit further investigation. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Firefighters Hematologic Tests Occupational Health Safety
• Keywords:
  Author Keywords: Environmental Exposures Blood Samples Chemicals DNA Damage Epigenetic Age Epigenomics Firefighter Fire Fighters Occupational Exposures Per- And Polyfluoroalkyl Substances PFAS

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• ISSN:
  1750-1911
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; California ; Florida ; Georgia ; Massachusetts ; Michigan ; New Jersey ; Ohio ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 8 ; OSHA Region 9 ; Rhode Island ; Utah ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  20
• NIOSHTIC Number:
  nn:20063949
• Citation:
  Epigenomics 2021 Oct; 13(20):1619-1636
• Contact Point Address:
  Jefferey L. Burgess, Department of Community, Environment & Policy, University of Arizona Mel & Enid Zuckerman College of Public Health, Tucson, AZ 85724
• Email:
  jburgess@email.arizona.edu
• CAS Registry Number:
  Perfluorocarbons (CAS RN 308069-13-8)
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  True
• Source Full Name:
  Epigenomics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f0611e5882938dfb4aff00e3a08cd6cfe5aa629e1f25d4561e386e030c6f0e86e5c7a18e482e8341d1de586ac2ffd01f7e47ce4629aede9a013bd06f603dc3ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/222482/cdc_222482_DS1.pdf
• File Type:
  [PDF - 833.43 KB ]