Liquefied Petroleum Gas or Biomass Cooking and Severe Infant Pneumonia

Details

• Personal Author:
  Balakrishnan K ; Castañaza A ; Chang HH ; Checkley W ; Chen Y ; Clasen TF ; Davila-Roman VG ; Diaz-Artiga A ; Garg SS ; Goodman-Palmer D ; Grajeda LM ; Hartinger SM ; Hossen S ; Jabbarzadeh S ; Johnson MA ; Kirby MA ; Lovvorn AE ; McCollum ED ; McCracken JP ; Moulton LH ; Mukeshimana A ; Naeher LP ; Nicolaou L ; Papageorghiou AT ; Peel JL ; Pillarisetti A ; Rosa G ; Rosenthal JP ; Simkovich SM ; Steenland, Kyle ; Thangavel G ; Thompson LM ; Underhill LJ ; Waller LA ; Wang J ; Williams KN ; Ye W
• Corporate Authors:
  Household Air Pollution Intervention Network Investigators
• Description:
  BACKGROUND: Exposure to household air pollution is a risk factor for severe pneumonia. The effect of replacing biomass cookstoves with liquefied petroleum gas (LPG) cookstoves on the incidence of severe infant pneumonia is uncertain. METHODS: We conducted a randomized, controlled trial involving pregnant women 18 to 34 years of age and between 9 to less than 20 weeks' gestation in India, Guatemala, Peru, and Rwanda from May 2018 through September 2021. The women were assigned to cook with unvented LPG stoves and fuel (intervention group) or to continue cooking with biomass fuel (control group). In each trial group, we monitored adherence to the use of the assigned cookstove and measured 24-hour personal exposure to fine particulate matter (particles with an aerodynamic diameter of ≤2.5 µm [PM2.5]) in the women and their offspring. The trial had four primary outcomes; the primary outcome for which data are presented in the current report was severe pneumonia in the first year of life, as identified through facility surveillance or on verbal autopsy. RESULTS: Among 3200 pregnant women who had undergone randomization, 3195 remained eligible and gave birth to 3061 infants (1536 in the intervention group and 1525 in the control group). High uptake of the intervention led to a reduction in personal exposure to PM2.5 among the children, with a median exposure of 24.2 µg per cubic meter (interquartile range, 17.8 to 36.4) in the intervention group and 66.0 µg per cubic meter (interquartile range, 35.2 to 132.0) in the control group. A total of 175 episodes of severe pneumonia were identified during the first year of life, with an incidence of 5.67 cases per 100 child-years (95% confidence interval [CI], 4.55 to 7.07) in the intervention group and 6.06 cases per 100 child-years (95% CI, 4.81 to 7.62) in the control group (incidence rate ratio, 0.96; 98.75% CI, 0.64 to 1.44; P=0.81). No severe adverse events were reported to be associated with the intervention, as determined by the trial investigators. CONCLUSIONS: The incidence of severe pneumonia among infants did not differ significantly between those whose mothers were assigned to cook with LPG stoves and fuel and those whose mothers were assigned to continue cooking with biomass stoves. [Description provided by NIOSH]
• Subjects:
  Air Pollution, Indoor Fuel Oils Occupational Health Particulate Matter Pregnancy Respiratory Tract Diseases Safety
• Keywords:
  Children Cooking Equipment Fuels Indoor Air Pollution Intervention Effectiveness Liquified Petroleum Gas LPG Particulates Pneumonia
• ISSN:
  0028-4793
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; District of Columbia ; Georgia ; Maryland ; Massachusetts ; Missouri ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 7 ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  32-43
• Volume:
  390
• Issue:
  1
• NIOSHTIC Number:
  nn:20069302
• Citation:
  N Engl J Med 2024 Jan; 390(1):32-43
• Contact Point Address:
  Dr. Checkley, Division of Pulmonary and Critical Care, Johns Hopkins University, 1830 E. Monument St., Ste. 555, Baltimore, MD 21287
• Email:
  wcheckl1@jhmi.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  New England Journal of Medicine
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8c70e30ee3abb94dfbb8c06172a796d5a38e661010e4a2b2e0938254b9caf9e50a62ee612fd159d1a234ce1dc467a66dc7ea4427ac085877bc35d3bd59159adc
• Download URL:
  https://stacks.cdc.gov/view/cdc/207804/cdc_207804_DS1.pdf
• File Type:
  [PDF - 638.65 KB ]