Lung Toxicity, Deposition, and Clearance of Thermal Spray Coating Particles with Different Metal Profiles After Inhalation in Rats (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Download the Dataset decsribed here from Data.cdc.gov at https://doi.org/10.26616/NIOSHRD-1079-2024-0. ; Thermal spray coating is a process in which molten metal is sprayed onto a surface. Little is known about the health effects associated with these aerosols. Sprague-Dawley rats were exposed to aerosols (25 mg/m3 x 4 hr/d x 4 d) generated during thermal spray coating using different consumables i.e., stainless-steel wire (PMET731), Ni-based wire (PMET885), Zn-based wire (PMET540). Control animals received air. Bronchoalveolar lavage was performed at 4 and 30 d post-exposure to assess lung toxicity. The particles were chain-like agglomerates and similar in size (310-378 nm). Inhalation of PMET885 aerosol caused a significant increase in lung injury and inflammation at both time points. Inhalation of PMET540 aerosol caused a slight but significant increase in lung toxicity at 4 but not 30 d. Exposure to PMET731 aerosol had no effect on lung toxicity. Overall, the lung responses were in the order: PMET885>>PMET540>PMT731. Following a shorter exposure (25 mg/m3 x 4 h/d x 1d), lung burdens of metals from the different aerosols were determined by ICP-AES at 0, 1, 4 and 30 d post-exposure. Zn was cleared from the lungs at the fastest rate with complete clearance by 4 d post-exposure. Ni, Cr, and Mn had similar rates of clearance as nearly half of the deposited metal was cleared by 4 d. A small but significant percentage of each of these metals persisted in the lungs at 30 d. The pulmonary clearance of Fe was difficult to assess because of inherently high levels of Fe in control lungs. Description provided by NIOSH
• Subjects:
  • Aerosols
  • Animals
  • Lung
  • Occupational Health
  • Particulate Matter
  • Respiratory System
  • Safety
  • Toxicology
• Keywords:
  • Sprays
  • Protective coatings
  • Aerosols
  • Inhalation
  • Animal studies
  • Lung tissue
  • Cellular effects
  • Metal oxides
  • Nanotoxicology
  • Particulates
• Series:
  NIOSH Data
• DOI:
  https://doi.org/10.26616/NIOSHRD-1079-2024-0
• Landing Page:
  https://stacks.cdc.gov/view/cdc/207614
• Dataset Download URL:
  https://data.cdc.gov/download/2se8-zi9r/application%2Fx-zip-compressed
• Identifier:
  https://doi.org/10.26616/NIOSHRD-1079-2024-0
• Format:
  ZIP folder
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• Media Type:
  application/zip
• Described By Type:
  HTML Repository Page
• License:
  https://creativecommons.org/public-domain/
• Rights:
  Public Domain
• Described By:
  https://stacks.cdc.gov/view/cdc/207614
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Contact Point:
  Health Effects Laboratory Division (HELD). Pathology and Physiology Research Branch (PPRB)
• Pages in Document:
  1 ZIP folder
• NIOSHTIC Number:
  nn:20069065
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1079-2024-0, 2024 Apr; :dataset
• Email:
  sa-cin-webteam@cdc.gov
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  False
• Download URL:
  https://stacks.cdc.gov/view/cdc/207614/cdc_207614_DS1.pdf
• File Type:
  [PDF - 141.19 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:424fcba355025e618cbd623376e752933c487536275c758ecb6c303c113019a4f80f0ddd7d54863852378fa8ea720ca2fee457ebcb0165d11f62d796204814e5