Associations Between Obstructive Sleep Apnea and COVID-19 Infection and Hospitalization Among US Adults

Details

• Personal Author:
  Barger LK ; Booker LA ; Czeisler MÉ ; Czeisler, Charles A. ; Howard ME ; Jackson ML ; Lane R ; McDonald CF ; Quan SF ; Rajaratnam SMW ; Ridgers A ; Robbins R ; Varma P ; Weaver MD
• Description:
  STUDY OBJECTIVES: Medical comorbidities increase the risk of severe COVID-19 infection. In some studies, obstructive sleep apnea (OSA) has been identified as a comorbid condition that is associated with an increased prevalence of COVID-19 infection and hospitalization, but few have investigated this association in a general population. This study aimed to answer the following research question: In a general population, is OSA associated with increased odds of COVID-19 infection and hospitalization and are these altered with COVID-19 vaccination? METHODS: This was a cross-sectional survey of a diverse sample of 15,057 US adults. RESULTS: COVID-19 infection and hospitalization rates in the cohort were 38.9% and 2.9%, respectively. OSA or OSA symptoms were reported in 19.4%. In logistic regression models adjusted for demographic, socioeconomic, and comorbid medical conditions, OSA was positively associated with COVID-19 infection (adjusted odds ratio: 1.58, 95% CI: 1.39-1.79) and COVID-19 hospitalization (adjusted odds ratio: 1.55, 95% CI: 1.17-2.05). In fully adjusted models, boosted vaccination status was protective against both infection and hospitalization. Boosted vaccination status attenuated the association between OSA and COVID-19 related hospitalization but not infection. Participants with untreated or symptomatic OSA were at greater risk for COVID-19 infection; those with untreated but not symptomatic OSA were more likely to be hospitalized. CONCLUSIONS: In a general population sample, OSA is associated with a greater likelihood of having had a COVID-19 infection and a COVID-19 hospitalization with the greatest impact observed among persons experiencing OSA symptoms or who were untreated for their OSA. Boosted vaccination status attenuated the association between OSA and COVID-19-related hospitalization. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Epidemiology Occupational Health Safety
• Keywords:
  Author Keywords: COVID-19 COVID-19 Cross Sectional Studies Disease Incidence Health Care Hospitalization Infection Obstructive Sleep Apnea Sleep Apnea Vaccines
• ISSN:
  1550-9389
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  7
• NIOSHTIC Number:
  nn:20069013
• Citation:
  J Clin Sleep Med 2023 Jul; 19(7):1303-1311
• Contact Point Address:
  Stuart F. Quan, MD, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115
• Email:
  Stuart_Quan@hms.harvard.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  Brigham and Women's Hospital, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20190901
• Source Full Name:
  Journal of Clinical Sleep Medicine
• End Date:
  20230831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:66a498d13d06526d5c4f4271967358c1f5728977bc9d29c1bb3d153c6e4f30f61572b032a3b7e7cff168fb582415ebd7469f4b2219e3505d9ad35a6c8bbc9bf8
• Download URL:
  https://stacks.cdc.gov/view/cdc/207569/cdc_207569_DS1.pdf
• File Type:
  [PDF - 530.12 KB ]