Association of Obstructive Sleep Apnea with Post-Acute Sequelae of SARS-CoV-2 Infection

Details

• Personal Author:
  Barger LK ; Booker LA ; Czeisler MÉ ; Czeisler, Charles A. ; Howard ME ; Jackson ML ; Lane RI ; McDonald CF ; Quan SF ; Rajaratnam SMW ; Ridgers A ; Robbins R ; Varma P ; Weaver MD ; Wiley JF
• Description:
  Background: Obstructive sleep apnea is associated with COVID-19 infection. Less clear is whether obstructive sleep apnea is a risk factor for the development of post-acute sequelae of SARS-CoV-2 infection (PASC). Study Design: Cross-sectional survey of a general population of 24,803 US adults to determine the association of obstructive sleep apnea with PASC. Results: COVID-19 infection occurred in 10,324 (41.6%) participants. Prevalence of persistent (>3 months post infection) putative PASC-related physical and mental health symptoms ranged from 6.5% (peripheral edema) to 19.6% (nervous/anxious). In logistic regression models, obstructive sleep apnea was associated with all putative PASC-related symptoms with the highest adjusted odds ratios being fever (2.053) and nervous/anxious (1.939). In 4 logistic regression models of overall PASC derived from elastic net regression, obstructive sleep apnea was associated with PASC (range of adjusted odds ratios: 1.934-2.071); this association was mitigated in those with treated obstructive sleep apnea. In the best fitting overall model requiring ≥3 symptoms, PASC prevalence was 21.9%. Conclusion: In a general population sample, obstructive sleep apnea is associated with the development of PASC-related symptoms and a global definition of PASC. Treated obstructive sleep apnea mitigates the latter risk. The presence of 3 or more PASC symptoms may be useful in identifying cases and for future research. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Mental Health Nervous System Occupational Health Safety
• Keywords:
  Author Keywords: COVID-19 COVID-19 Cross Sectional Studies Infectious Diseases Long COVID Mental Health Obstructive Sleep Apnea PASC Post-acute Sequelae Of SARS-CoV-2 Infection SARS-CoV-2 Sleep Apnea

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• ISSN:
  0002-9343
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  137
• Issue:
  6
• NIOSHTIC Number:
  nn:20069528
• Citation:
  Am J Med 2024 Jun; 137(6):529-537.e3
• Contact Point Address:
  Stuart F. Quan, MD, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115
• Email:
  Stuart_Quan@hms.harvard.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  Brigham and Women's Hospital, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20190901
• Source Full Name:
  The American Journal of Medicine
• End Date:
  20230831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9889feed6835cc0eb02302d4fbff069bb31ced825e2be46c2ba6309898f90c2e55275000a20160a077a9ad3dc4b2515a604d1f6cb3f20c0cbd146f73e6a77c60
• Download URL:
  https://stacks.cdc.gov/view/cdc/207949/cdc_207949_DS1.pdf
• File Type:
  [PDF - 298.56 KB ]