Inconsequential Role for Chemerin-Like Receptor 1 in the Manifestation of Ozone-Induced Lung Pathophysiology in Mice (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Chemerin, a non-chemokine chemoattractant, and resolvin E1 (RvE1), a specialized pro-resolving lipid mediator, are endogenous ligands for chemerin-like receptor 1 (CMKLR1), a Gi/o protein-coupled receptor expressed by leukocytes and non-leukocytes. In mice, exogenous administration of chemerin or RvE1 diminishes the severity of lung inflammation and airway hyperresponsiveness (AHR) induced by antigen sensitization and challenge, which mimics phenotypic features of atopic asthma in humans. However, the contribution of chemerin or RvE1 to features of non-atopic asthma is unknown. Therefore, to indirectly assess if chemerin or RvE1 facilitates development of a non-atopic asthma phenotype, which includes AHR to acetyl-β-methylcholine chloride, lung hyperpermeability, airway epithelial cell desquamation, and lung inflammation, we quantified features of these sequelae in wild-type mice and mice failing to express CMKLR1 (CMKLR1-deficient mice) following cessation of acute inhalation exposure to either filtered room air or ozone, a criteria pollutant and non-atopic asthma stimulus. [Description provided by NIOSH]
• Subjects:
  Animals Asthma Asthma, Occupational Blood Immune System Lung Macrophages Occupational Health Ozone Respiratory System Safety

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• Keywords:
  Airway Resistance Animal Studies Immune Reaction Inhalation Studies Leukocytes Lung Irritants Physiopathology
• DOI:
  https://doi.org/10.26616/NIOSHRD-1075-2023-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 6 ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20068758
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1075-2023-0, 2023 Nov; :dataset
• Contact Point Address:
  Pathology and Physiology Research Branch (PPRB), Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1000 Frederick Lane, Morgantown, WV 26508-5402. Tel: (304) 285-5831
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2024
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Inconsequential role for chemerin-like receptor 1 in the manifestation of ozone-induced lung pathophysiology in mice
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a5c38b7911b3fed3e475089c6a1bb3546440ccd14e0288dc09c11ff221d48d96811f9507d004c030fcfd81b52586efcc3ceb3d0e83c120c731da8c04c7642153
• Download URL:
  https://stacks.cdc.gov/view/cdc/207341/cdc_207341_DS1.pdf
• File Type:
  [PDF - 105.75 KB ]