Use of immunologic technology in the diagnosis of environmental and occupational immunologic lung disease

Details

• Personal Author:
  Grammer LC ; Harris KE ; Patterson R ; Shaughnessy MA ; Zeiss CR
• Description:
  An overview of the usefulness and uncertainties of immunoassays in environmental and occupational lung diseases was presented. Information is presented on immunoassays of potential diagnostic value in immunologic lung diseases, lung disease due to reactive chemicals, examples of lung diseases due to inhaled agents, examples of inhaled substances producing immunologic lung disease, animal models used to confirm the immunopathogenesis of trimellitic- anhydride (552307) (TMA) pulmonary disease, and factors related to antigen and host or cohort. While the potential exists for defining other diseases as clearly as the model of TMA immunologic lung diseases, some of the variables that complicate this type of investigation are discussed. These include the possibility that the antigen is also an irritant, that the antigen cannot be measured in the environment, and that the antigen is present in the workplace and at home. Several factors related to the host or cohort also complicate the process. These include cigarette smoking, the presence of irreversible obstructive lung disease, coincidental allergic or nonallergic asthma, misinformation, fear, and compensation neurosis. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Dust Environmental Pollution Inhalation Exposure Laboratories Lung Occupational Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Airborne-dusts Environmental-contamination Immunodiagnosis Immunological-tests Inhalants Laboratory-animals NIOSH-Publication Occupational-diseases Pulmonary-function Respiratory-system-disorders
• ISSN:
  0012-3692
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  206-208
• Volume:
  98
• Issue:
  5
• NIOSHTIC Number:
  nn:00196533
• Citation:
  Chest 1990 Nov; 98(5):206-208
• CAS Registry Number:
  Trimellitic anhydride (CAS RN 552-30-7)
• Federal Fiscal Year:
  1991
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Chest
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2001d98d753970a555881233d60e6c761f5e6ac763c87a9d4822b772b0c999bb975c4ab37e69e0e42385f49c470c370e75285653f64729dc95a0eaf4dd439686
• Download URL:
  https://stacks.cdc.gov/view/cdc/205842/cdc_205842_DS1.pdf
• File Type:
  [PDF - 747.26 KB ]