The role of analytical techniques in the diagnosis of asbestos-associated disease

Details

• Personal Author:
  Abraham JL ; Green FHY ; Vallyathan V ; Abraham JL ; Green FHY ; Vallyathan V
• Description:
  Diagnosis of asbestos (1332214) related disease using light microscopy (LM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray energy spectrometry (XES), selected area electron diffraction (SAED), and x-ray diffractometry (XRD) was reviewed. Discussion involved consideration of the following: asbestos minerals; asbestos uses; exposure sources (occupational, avocational, environmental); clinical and radiological features of asbestos associated diseases; disease pathology (pleural plaques, asbestosis, asbestos bodies and fibers, bronchogenic carcinoma, malignant mesothelioma, other cancers); the role of adjunct diagnostic techniques (tissue sampling, autopsy, lung biopsy, LM, extraction from tissues, SEM, XES, TEM, aspect ratio measurements, SAED, automated image analysis, XRD); the clinical and epidemiological significance of asbestos bodies and fibers; and medicolegal considerations. It was stated that LM has been useful in identifying asbestos fibers in environmental samples and in determining asbestos bodies in tissue sections and digests. Transmission electron microscopes with XES and SAED capabilities were able to provide information on morphology, crystal structure, and chemical composition of asbestos fibers; SEM was considered less useful since it cannot provide for electron diffraction. The authors conclude that microanalytical techniques are useful for confirming asbestos exposure diagnoses. [Description provided by NIOSH]
• Subjects:
  Asbestos Diagnosis Inorganic Chemicals Lung Microbiology Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Asbestos-fibers Clinical-diagnosis Clinical-pathology Diagnostic-techniques Lung-fibrosis Microscopic-analysis NIOSH-Author Respiratory-system-disorders
• ISSN:
  1040-8363
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-42
• Volume:
  22
• Issue:
  1
• NIOSHTIC Number:
  nn:00205416
• Citation:
  Crit Rev Clin Lab Sci 1985 Jan; 22(1):1-42
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  1985
• NORA Priority Area:
  Pulmonary System Disorders ; Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Critical Reviews in Clinical Laboratory Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6ad3d53a3ee83357bb6b074fc4b8098e0636e5748b8b10a6c61cc1d1aec55011bc78a4b00591516bda5660ad87eba359851474f8eadd6d4c2ef60cf342beaac8
• Download URL:
  https://stacks.cdc.gov/view/cdc/205770/cdc_205770_DS1.pdf
• File Type:
  [PDF - 3.43 MB ]