Structural equation modeling and nested ANOVA: effects of lead exposure on maternal and fetal growth in rats

Details

• Personal Author:
  Gartside PS ; Hamilton JD ; O'Flaherty EJ ; Ross R ; Shukla R
• Description:
  The effects of lead (7439921) exposure on maternal and fetal growth were examined using structural equation modeling and nested analysis of variance (ANOVA) in rats. Lead-acetate (301042) was administered in drinking water to female Sprague-Dawley-rats ad-libitum beginning at day 25 of age. Doses ranged from 250 to 1,000 parts per million lead. Lead exposure had a direct negative effect on body weight and growth (tail length) during the first week of exposure. During the next 2 weeks of exposure, a high correlation between growth indices and food intake over time resulted in an apparent reduction in early postnatal growth. These effects were reversible, since reduced growth was not evident beyond the third week of exposure. Mating began after 8 weeks of exposure and exposure continued during the gestation period. Lead exposure was associated with a decrease in fetal body weight when effects of litter size, intrauterine position, and sex were controlled in a nested ANOVA. The authors conclude that lead exposure did not appear to affect fetal skeletal development, possibly because lead did not alter levels of maternal serum calcium and phosphorus. [Description provided by NIOSH]
• Subjects:
  Laboratories Lead Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Analytical-methods Developmental-disorders Growth-rate Laboratory-animals Lead-compounds Long-term-exposure NIOSH-Grant NIOSH-Publication Reproductive-hazards Reproductive-system-disorders Transplacental-exposure

  More +
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  53-64
• Volume:
  64
• Issue:
  1
• NIOSHTIC Number:
  nn:00219515
• Citation:
  Environ Res 1994 Jan; 64(1):53-64
• Contact Point Address:
  Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, OH 45267
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Lead diacetate (CAS RN 301-04-2)
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Reproductive System Disorders
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Start Date:
  19870501
• Source Full Name:
  Environmental Research
• End Date:
  19900430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a1fa2249868ac41e8db636d33cd88aef8d42c306a492a108890f278705abd9393f8d28bed9391e223dfd54f4ca4226c675cd0ce80474a06408d43d9b60aa2481
• Download URL:
  https://stacks.cdc.gov/view/cdc/205632/cdc_205632_DS1.pdf
• File Type:
  [PDF - 607.54 KB ]