Soft tissue sarcoma and non-Hodgkin's lymphoma in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: two nested case-control studies

Details

• Personal Author:
  Becher H ; Benn T ; Bertazzi, Pier A. ; Bueno-de-Mesquita HB ; Coggon D ; Green L ; Johnson E ; Kauppinen T ; Kogevinas M ; Littorin M ; Lynge E ; Marlow, David A. ; Mathews JD ; Neuberger M ; Pannett B ; Pearce N ; Saracci-R ; Winkelmann R
• Description:
  A study was conducted on the risk of soft tissue sarcoma and nonHodgkin's lymphoma among an international cohort of workers exposed to phenoxy herbicides or chlorophenols. Data on mortality of phenoxy herbicide or chlorophenol exposed workers due to soft tissue sarcoma and nonHodgkin's lymphoma were obtained from the International Agency for Research on Cancer. Excess risk for soft tissue sarcoma was seen for those exposed to any phenoxy herbicides, such as 2,4-dichlorophenoxyacetic-acid (94757) (2,4-D), 2,4,5- trichlorophenoxyacetic-acid (93765) (2,4,5-T), 4-chloro-2- methylphenoxyacetic-acid (94746), to any polychlorinated dibenzodioxin or furan, and to 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD). A dose response relationship was observed for 2,4- D, 2,4,5-T, TCDD, and any polychlorinated dibenzodioxin. Associations of chemical exposure with nonHodgkin's lymphoma were generally lower than those seen for soft tissue sarcoma. Excess risk for exposure to 2,4,5-T, TCDD, and polychlorinated dibenzodioxins or furans was approximately twofold for this disease while a threefold increased risk was observed for exposure to pentachlorophenol (87865) or gamma-butyrolactone (96480). Dose response relationships were identified for lymphoma and 2,4,5-T and any polychlorinated dibenzodioxin or furan. [Description provided by NIOSH]
• Subjects:
  Dioxins Insecticides Mortality Neoplasms Occupational Exposure Occupational Health Polychlorinated Biphenyls Safety
• Keywords:
  Author Keywords: Soft Tissue Sarcoma Cancer-rates Case-control Study Chlorinated-phenols Dioxin Mortality-data Mortality-rates NIOSH-Author Non-Hodgkins Lymphoma Occupational-exposure Pesticides Phenoxy Herbicides Polychlorinated-hydrocarbon-pesticides

  More +
• ISSN:
  1044-3983
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  396-402
• Volume:
  6
• Issue:
  4
• NIOSHTIC Number:
  nn:00229400
• Citation:
  Epidemiology 1995 Jul; 6(4):396-402
• CAS Registry Number:
  (2,4-Dichlorophenoxy)acetic acid (CAS RN 94-75-7) ; (4-Chloro-2-methylphenoxy)acetic acid (CAS RN 94-74-6) ; 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; Pentachlorophenol (CAS RN 87-86-5) ; Trichlorophenoxyacetic acid (CAS RN 93-76-5) ; γ-Butyrolactone (CAS RN 96-48-0)
• Federal Fiscal Year:
  1995
• Peer Reviewed:
  True
• Source Full Name:
  Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a55beda4799e2545836f424ff074e4c2659fa4042cac7646f8a69ed53b3c51175cf4e41fc290630b33ca235c7abcea117e2d52e739f01621d73d6cbd6ee9d5e8
• Download URL:
  https://stacks.cdc.gov/view/cdc/205613/cdc_205613_DS1.pdf
• File Type:
  [PDF - 2.55 MB ]