Sister-chromatid exchanges in lymphocytes are increased in relation to longitudinally measured occupational exposure to low concentrations of styrene

Details

• Personal Author:
  Paradisin WM ; Rappaport SM ; Yager JW
• Description:
  A study was conducted on the dose response relationship between styrene (100425) exposure and the induction of genotoxicity. Blood samples were obtained from workers in a boat manufacturing facility and the presence of sister chromatid exchanges and micronuclei in lymphocytes and styrene and styrene-glycol concentrations in the blood were determined. Occupational exposures to styrene were monitored as well over the course of 1 year. The highest exposure levels were seen in laminators, chopper gun operators, and mold repairers. Linear regression analyses demonstrated that the incidence of sister chromatid exchanges was significantly increased in cigarette smokers and in those exposed to a mean air concentration of styrene of 64.2mg/m3. It was estimated that about 25% of the variability in sister chromatid exchanges seen in this cohort could be accounted for by exposure to styrene and 62% by cigarette smoking. No effects of styrene exposure on the frequency of micronuclei were seen. [Description provided by NIOSH]
• Subjects:
  Blood Occupational Exposure Occupational Health Safety Ships Smokers Styrene Tobacco Products
• Keywords:
  Age Author Keywords: Sister-chromatid Exchange Boat-manufacturing-industry Cigarette-smoking Cytokinesis-block Dose-response Gender Genotoxic-effects Grants-other Intra- And Inter-individual MN Longitudinal Low-level Exposure Lymphocytes Micronuclei MN NIOSH-Grant NIOSH-Publication Occupational-exposure Occupational Exposure SCE

  More +
• ISSN:
  0027-5107
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  155-165
• Volume:
  319
• Issue:
  3
• NIOSHTIC Number:
  nn:00217675
• Citation:
  Mutat Res 1993 Nov; 319(3):155-165
• Contact Point Address:
  Biomedical & Environ Hlth Scis University of California School of Public Health Berkeley, CA 94720
• CAS Registry Number:
  Styrene (CAS RN 100-42-5)
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Other Occupational Concerns
• Performing Organization:
  University of California Berkeley, Berkeley, California
• Peer Reviewed:
  True
• Start Date:
  19850901
• Source Full Name:
  Mutation Research
• End Date:
  19931227
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:69985a9430992cea8bc7f929801532112340adc678f94722a64e54b48d56fc8233e6feca5f07f5457f629be8839f128c0d7954cd037a4f55babadbcf77a6524c
• Download URL:
  https://stacks.cdc.gov/view/cdc/205609/cdc_205609_DS1.pdf
• File Type:
  [PDF - 851.25 KB ]